Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound has been suggested to enhance transfection decades ago, it took a combination of ultrasound with nucleic acid carrier systems (microbubbles, liposomes, polyplexes, and viral carriers) to achieve reasonable nucleic acid delivery efficacy. Microbubbles serve as foci for local deposition of ultrasound ener...

Conventional Canny edge detector can detect edges in image with additive noise effectively but not ultrasound image that are corrupted by multiplicative speckle noise which alleviates image resolution resulting in inaccurate characterization of object features. In this paper, we proposed to incorporate the modified SRAD into the Canny edge detector to replace the Gaussian blurring in the conven...

Ultrasound elastography is an imaging modality to evaluate elastic properties of soft tissue. Recently, 1D quasi-static elastography method has been commercialized by some companies. However, its performance is still limited on high strain level. In order to improve the precision of estimation during high compression, some algorithms have been proposed to expand the 1D window to a 2D window for...

Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsi...

Background & Objective: Modified Ultra-fast Papanicolaou (MUFP) stain has been developed from Papanicolaou stain (PAP) with the...

The modified synthetic transmit aperture (STA) algorithm is described. The primary goal of this work was to assess the possibility to improve the image quality achievable using synthetic aperture (SA) approach and to evaluate the performance and the clinical applicability of the modified algorithm using phantoms. The modified algorithm is based on the coherent summation of back-scattered RF ech...

The usage of ultrasound imaging for medical diagnosis is limited due to the presence of speckle noise. In this study Modified Adaptive Wavelet Shrinkage Filter (MAWSF) in the translational invariant domain is proposed for the removal of speckle noise. The adaptive wavelet threshold function removes the fixed bias of soft thresholding. A new inter-scale dependency model is proposed, to perform a...