LABORATORY DATA biochemical markers metabolic defect chromosomal assignment chromosome 5q localization gene, structural-functional anomalies CNCG tissue cyclic nucleotide gated channel photoreceptor gene analysis-DNA analysis Marineso-Sjogren syndrome ( MSS) gene chr.5q31 pituitary hormones, modified functions follicle-stimulating hormone, gonadotrophin (FSH) , high levels luteinizing hormone, ...

This work considers the rigorous derivation of continuum models of step motion starting from a mesoscopic Burton–Cabrera–Frank-type model following the Xiang’s work (Xiang in SIAM J Appl Math 63(1):241–258, 2002). We prove that as the lattice parameter goes to zero, for a finite time interval, a modified discrete model converges to the strong solution of the limiting PDE with first-order conver...

Recently many mathematical models for image processing have been widely applied in computer visualization. The nonlinear diffusion PDE has been broadly applied in image processing. In this paper we propose a convection-diffusion filter by adding a convection term in the modified diffusion equation as a physical interpretation for removing the noise. We study the dynamics of such equations by th...

In rod outer segments the light activation of cGMP phosphodiesterase (PDE alpha beta gamma 2) is accomplished by removal of the gamma inhibitory subunit (PDE gamma) from the PDE alpha beta catalytic subunits. A light activation of the inositol signaling pathway also occurs, but there is little information linking these two signal transduction pathways. Here we report that protein kinase C (PKC)...

Shape optimization problems frequently take the form of finding parameters that describe the shape of an object or a region in order to minimize a given design objective (such as weight or drag). In many practical situations, the behavior of states in the system can be modeled as the solution to a partial differential equation (PDE). Calculating the dependence of the state solution on these sha...

Four cyclic nucleotide phosphodiesterase (PDE) activities were separated from low-speed supernatants of homogenates of human cardiac ventricle by DEAE-Sepharose chromatography, and designated PDE I-PDE IV in order of elution with an increasing salt gradient. PDE I was a Ca2+/calmodulin-stimulated activity, and PDE II was an activity with a high Km for cyclic AMP which was stimulated by low conc...

1 The aims of the present study were to characterize the cyclic nucleotide phosphodiesterase (PDE) isoenzyme activities present in human bronchi and to examine the ability of selective isoenzyme inhibitors to relax histamine and methacholine precontracted preparations of human bronchi. 2 Three separations of pooled human bronchial tissue samples were performed. Ion-exchange chromatography showe...

The effect of selective PDE-I (vinpocetine), PDE-III (milrinone, CI-930), PDE-IV (rolipram, nitroquazone), and PDE-V (zaprinast) isozyme inhibitors on TNF-alpha and IL-1beta production from LPS stimulated human monocytes was investigated. The PDE-IV inhibitors caused a concentration dependent inhibition of TNF-alpha production, but only partially inhibited IL-1beta at high concentrations. High ...

Abstract The long-time behaviour of solutions to the defocussing modified Korteweg-de Vries (MKdV) equation is established for initial conditions in some weighted Sobolev spaces. Our approach based on nonlinear steepest descent method Deift and Zhou its reformulation by Dieng McLaughlin through $\overline {\partial }$ -derivatives. To extend asymptotics with data lower-regularity spaces, we app...