Coal quality-tonnage curves are helpful tools in optimum mine planning and can be estimated using geostatistical simulation methods. In the presence of spatially cross-correlated variables, traditional co-simulation methods are impractical and time consuming. This paper investigates a factor simulation approach based on minimization of spatial cross-correlations with the objective of modeling s...

The c-maf transcription factor is selectively expressed in IL-4-producing Th2 cells. It has been implicated in IL-4 gene transcription based on its ability to directly activate the IL-4 gene in nonexpressing B cells and to promote IL-4-induced Th2 differentiation. However, it has not been definitively shown that IL-4 production by other cells is dependent on the presence of c-maf. Here, we show...

Background: Metabolic syndrome (Mets) is partially heritable. High mobility group AT-hook1 (HMGA1), an architectural transcription factor, affects the homeostasis of glucose. The marked inter-individual differences between T2DM patients in response to oral anti-diabetic drugs have become issue for effective prescribing and dosing. objective this study was designed assess whether different SNPs ...

objective(s) the objective of this study was to prepare, characterize and evaluate the nanoliposomes containing safranal as a natural sunscreen and moisturizer factor. materials and methods the experimental formulations included homosalate reference, nanoliposomes containing 0.25, 0.5, 1, 2, 4 and 8% safranal and empty liposomes. the liposomes were prepared using fusion method and homogenizatio...

Increasing the hydrophobicity of membrane was believed as an effective approach to enhance the performance of organophilic pervaporation (PV) membrane. In this work, the superhydrophobic alkyl group modificated metal organic framework (MOF) of RHO-[Zn(eim)2] (MAF-6) was incorporated into polydimethylsiloxane (PDMS) polymer to fabricate mixed matrix membranes (MMMs). The morphologies, physical a...

objective: to determine the reliability and validity of the revised dyadic adjustment scale (rdas) with 14 items (short form) in iranian population. methods:the english version of the rdas was translated into persian. then, persian version was retranslated to english. to study factor structure 338 questionnaires were filled out by parents of elementary students. other measurement tools were the...

Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as k...

Osteopetrosis is a heterogeneous group of bone disorders characterized by the failure of osteoclasts to resorb bone and by several immunological defects including macrophage dysfunction. Two compounds, colony-stimulating factor-1 (CSF-1) and vitamin D-binding protein-macrophage activating factor (DBP-MAF) were used in the present study to evaluate their effects on the peritoneal population of c...

Although c-Maf is crucial for Th2 differentiation and production of interleukin 4 (IL-4), its regulation is poorly understood. We report that Vav1-/- CD4+ T cells display deficient T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, enhanced interferon gamma (IFN-gamma) production and T-bet expression (even when cultured under Th2-polarizing conditions), but intact exp...