نتایج جستجو برای: molecular histopathology
تعداد نتایج: 659372 فیلتر نتایج به سال:
The diagnosis of cancer relies primarily on invasive tissue biopsy, as noninvasive diagnostic tests are generally insufficient to define a disease process of cancer. The conventional histopathology based on light microscopy, however, has recently been complemented with ultrastructure, immunohistochemistry and molecular diagnostics. Molecular medicine has led to the discovery and application of ...
INTRODUCTION Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. We tested the hypothesis that non-invasive optical tomographic imaging of molecular biomarkers of inflammation and bone turnover would provide a superior quantitative readout a...
BACKGROUND In celiac disease (CD), intestinal epithelium damage occurs secondary to an immune insult and is characterized by blunting of the villi and crypt hyperplasia. Similarities between Hedgehog (Hh)/BMP4 downregulation, as reported in a mouse model, and CD histopathology, suggest mechanistic involvement of Hh/BMP4/WNT pathways in proliferation and differentiation of immature epithelial ce...
Brain tumors show genetic heterogeneity and various immunohistochemical / biomarkers are now available for brain tumor diagnosis in addition to the advanced molecular techniques. However the basic routine histopathology remains the gold standard for diagnosis corroborating with the characteristic radiology and immunohistochemistry to substantiate or confirm diagnosis and MIB1/Ki67 for grading o...
Abstract Background Primary pilocytic astrocytoma of the CPA (Cerebello-pontine angle), in pediatric age group is an extremely rare entity, with just three cases reported so far. It mostly arises from root entry zone cranial nerves found this cistern. Case presentation A 11-year boy presented headache, hearing impairment right ear. Pure tone audiogram and BAER (Brainstem auditory evoked respons...
INTRODUCTION Esophageal involvement in patients with systemic sclerosis (SSc) is common, but tissue-specific pathological mechanisms are poorly understood. There are no animal scleroderma esophagus models and esophageal smooth muscle cells dedifferentiate in culture prohibiting in vitro studies. Esophageal fibrosis is thought to disrupt smooth muscle function and lead to esophageal dilatation, ...
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