This issue's Molecular Medicine Select describes recent progress in identifying pathways that dampen inflammation in multiple disease contexts including allergic skin reactions, demyelinating diseases, and neuro-degeneration. In addition to revealing new potential therapeutic targets, these efforts also put a spotlight on small molecules, including cannabinoids and compounds derived from omega-...

Metastasis is a multistep process in which primary tumor cells are re-established at distant organ sites and develop into secondary tumors. It accounts for the majority of deaths among patients with solid tumors, necessitating better elucida-tion of the mechanisms involved and development of new therapies to specifically block this process. One of the initiating events implicated in the onset o...

  Purpose: To evaluate the effect of fullerene on chemical properties of naphazoline drug in   water by density functional theory (DFT) methods.   Materials and Methods: Naphazoline belongs to the imidazoline class of sympathomimetics.   The present study on naphazoline drug and its fullerene connected form were carried out using   computerized calculations of Gaussian program in b3lyp/6-31g le...

Small noncoding RNAs, including endogenous antisense RNAs and microRNAs, are involved in many different cellular processes. This issue's Molecular Medicine Select highlights recent work investigating the roles of these RNAs in various aspects of tumorigenesis, suggesting new prognostic, and possibly therapeutic, tools for treating cancer. MicroRNAs (miRNAs) are small noncoding RNAs that negativ...