The sample treatment/preparation steps involve any operation and manipulation of the samples prior to instrumental determination of the target compounds [1−3]. This is a critical step in the analytical process because the concentration of target analytes in the samples is frequently too low for quantification. Thus, the first step of the preparation protocol involves the exhaustive extraction/c...

Artificial receptors have been in use for several decades as sensor elements, in affinity separation, and as models for investigation of molecular recognition . Although there have been numerous publications on the use of molecular modeling in characterization of their affinity and selectivity, very few attempts have been made on the application of molecular modeling in computational design of ...

Highly cross-linked 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) dimethacrylate with poly(ethylene glycol) of molecular weight 600 (PEG600DMA) were molecularly imprinted with hydrophilic templates glucose and proxyphylline using water as a solvent. Glucose-imprinted polymers showed increased recognitive capacity compared to nonimprinted polymers as well as increased glucose upta...

This is the first direct experimental probe, using EXAFS, of the active site within molecularly imprinted polymers and paves the way to a more detailed understanding of the inner workings of molecular imprinting.

In the current study, piezosensors based on molecularly imprinted polyimides with imprints of potassium sorbate and sodium benzoate were obtained. Molecularly Imprinted Polymers (MIPs) synthesized using a polyimide non-covalent imprinting technique. It was established that use 0.1 g/mL template concentration at thermochemical stage led to formation maximum number molecular film surface. Using s...

The isolation and preconcentration of estrogens from new types of biological samples (acellular and protein-free simulated body fluid) by molecularly imprinted solid-phase extraction has been described. In this technique, supramolecular receptors, namely molecularly imprinted polymers (MIPs) are used as a sorbent material. The recognition sites of MIPs were prepared by non-covalent multiple int...

We present a previously undescribed initiative and its application, namely the design of molecularly imprinted polymers (MIPs) for producing protein crystals that are essential for determining high-resolution 3D structures of proteins. MIPs, also referred to as "smart materials," are made to contain cavities capable of rebinding protein; thus the fingerprint of the protein created on the polyme...

Molecular imprinting is a technique for making a selective binding site for a specific chemical. The technique involves building a polymeric scaffold of molecular complements containing the target molecule. Subsequent removal of the target leaves a cavity with a structural "memory" of the target. Molecularly imprinted polymers (MIPs) can be employed as selective adsorbents of specific molecules...

Molecularly imprinted technology (MIT) has the characteristics of specificity and high selectivity, which is one of the most promising methodologies. Besides, the polymers are made using MIT as the functional material of solid-phase extraction and chromatographic fractionating and sensor, because of the characteristics of the high selectivity, the better stability and easy preparation. This rev...

Sample preparation is often the rate-limiting step in analytical methods and its effectiveness has a critical impact on accuracy, quantification and, ultimately, the precision of any measurement. Traditionally, liquid–liquid extraction methods are frequently used for the extraction of organic analytes from aqueous samples. To overcome some of the disadvantages of liquid–liquid extraction (e.g.,...