Treatment of pain associated with osteoarthritis (OA) is unsatisfactory and innovative approaches are needed. The secretome from human adipose-derived mesenchymal stem cells (hASC-Conditioned Medium, CM) has been successfully used to relieve painful symptoms in models chronic pain. aim this study was explore the efficacy hASC-CM control neuroinflammation an animal model OA. OA induced mice by i...

Latar Belakang: Osteoartritis (OA) merupakan penyakit degeneratif sendi yang disebabkan oleh faktor biomekanik dan biokimia (stress oksidatif). Stres oksidatif dapat meningkatkan terjadinya kerusakan pada kartilago sendi. Malondialdehid biomarker stres oksidatif.
 Objektif: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian mesenchymal stem cell Wharton’s Jelly terhadap kadar MDA...

BACKGROUND The incapacity of articular cartilage (AC) for self-repair after damage ultimately leads to the development of osteoarthritis. Stem cell-based therapy has been proposed for the treatment of osteoarthritis (OA) and induced pluripotent stem cells (iPSCs) are becoming a promising stem cell source. RESULTS Three steps were developed to differentiate human iPSCs into chondrocytes which ...

[Purpose] To investigate the correlation between the effect treadmill exercise and change in serum proteins in rats with osteoarthritis, a study of proteins was carried out using a mass spectrometer. [Subjects and Methods] Rats were randomly divided into five groups. After 4 weeks of treadmill training, serum from each rat was analyzed by Liquid chromatography-electrospray ionization tandem mas...

The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic dehydrogenase or beta-glucuronidase. A lytic phase involved the slower loss of ...

In order to study the effects of CO2 laser moxibustion on the pain and inflammatory cytokine expression in the spinal dorsal horn of rats with monosodium iodoacetate- (MIA-) induced knee osteoarthritis (KOA), we designed an experiment by randomly assigning 8 SD rats into 3 groups, namely, a CO2 laser moxibustion group, a sham treatment group, and a blank control group. The treatment group recei...