INTRODUCTION One of the most common complaints in patients with end-stage renal disease (ESRD) is uremic pruritus. In the recent years, many drugs have been proposed for its treatment which have had paradoxical outcomes. We studied the antipruritus effect of montelukast sodium, a leukotriene receptor antagonist, in patients on hemodialysis. MATERIALS AND METHODS The study was conducted as ran...

AIMS Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation. METHODS GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone. After 72 hours of the 7th inhalation, GP were anesthetised, and lungs were removed and submitted to ...

A new stability-indicating RP-HPLC method was developed for the simultaneous determination of fexofenadine hydrochloride and montelukast in combined dosage form, using a Aligent, Zorbax (Make: 150 mmx4.6 mm I.D; particle size 5μm and a mobile phase composed of phospahte buffer (pH 4.0): Acetonitile (60:40 v/v) at a flow rate of 1.0mL/min. The retention times of fexofenadine hydrochloride and mo...

Aphthous ulcers are the most prevalent oral mucosal lesions, yet treatment is challenging. There evidence that montelukast efficacious in treating aphthous ulcers. A randomized placebo-controlled trial comparing against prednisone for recurrent stomatitis demonstrated has superior efficacy compared with placebo, decreased prednisone, but adverse effects to prednisone. Our single-center, retrosp...

INTRODUCTION Uremic pruritus is one of the most common disabling symptoms in patients with end-stage renal disease. We aimed to study the effect of montelukast sodium for the treatment of uremic pruritus lasting more than 3 months in patients undergoing hemodialysis and compare it with placebo. METHODS AND MATERIALS Eighty patients undergoing hemodialysis at 3 centers in Shiraz, Iran, were re...

A simple, rapid, accurate, precise and economical reverse phase high performance liquid chromato graphic method has been developed for simultaneous estimation of Doxophylline and Montelukast sodium. The separation of drugs was achieved on Inertsil Ph-3 column (250 mmx4.6 mm id, 5 μm particle size) with mobile phase of Ammonium acetate 0.05milimolar and Glacial acetic acid buffer (pH 3.5): Metha...

A simple, specific, accurate, and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of montelukast and fexofenadine hydrochloride, using a Lichrospher(®) 100, RP-18e column and a mobile phase composed of methanol:0.1% o-phosphoric acid (90:10 v/v), pH 6.8. The retention times of montelukast and fexofenadine hydroc...

Quantitative image analysis of high-resolution computed tomography (HRCT) performed at residual volume, before and after methacholine, is a sensitive method of detecting small airways involvement in asthma and response to therapy targeted to the small airways. Since an oral anti-leukotriene reaches the small airways via the circulation, the present authors hypothesised that treatment with monte...

The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms. The study was a 12-month multicenter, double-blind, parallel-group study of patients with asthma exacerbations associated with respiratory infections and mini...

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...