Only a fraction of eukaryotic genes affect the phenotype drastically. We compared 18 parameters in 1273 human morbid genes, known to cause diseases, and in the remaining 16 580 unambiguous human genes. Morbid genes evolve more slowly, have wider phylogenetic distributions, are more similar to essential genes of Drosophila melanogaster, code for longer proteins containing more alanine and glycin...

The evolution of building codes typically produce design provisions that are expected to create safer and more accurate designs. We as engineers expect building codes to advance the state of the art with each successive edition. The 2009 International Building Code (IBC) and the Building Code Requirements for Structural Concrete (ACI 318-08) have significant revisions affecting the design of ti...

BACKGROUND Morbid obesity can be a life threatening condition. The aim of our study is to assess the trend in morbid obesity in The Netherlands among children of Dutch origin since 1980, and among children of Turkish and Moroccan origin since 1997. METHODS AND FINDINGS Cross-sectional height and weight data of children of Dutch, Turkish and Moroccan origin aged 2-18 years were selected from t...