Localized morphea is a disorder of unknown cause in which there is localized sclerosis of the skin. Disabling pansclerotic morphea of childhood is a rare severe mutilating form of morphea involving the dermis, fat, fascia, muscle and even bone, usually starting before the age of 14 years. Here, an eight-year-old boy with progressive sclerosis of palmar surface of wrist and hand and digits...

We describe a case of morphea which presented further typical lesions of the disease at the sites of mechanical trauma. It can be suggested that cutaneous lesions of morphea may be locally developed due to physical stimuli as an isomorphic response in patients or subclinical cases of the disease.

Introduction Morphea is a chronic autoimmune disease characterized by fibrosis of the skin. Dendritic cells (DC) and regulatory T cells (Tregs) play a significant role in development of autoimmune and tolerance mechanisms. The aim of the study was to establish the expression of selected genes of plasmacytoid and myeloid DC, Treg cells, and the microenvironment of cytokines (interleukin-17A (IL-...

OBJECTIVE To determine the prevalence of extracutaneous manifestations and autoimmunity in adult and pediatric patients with morphea. DESIGN A retrospective review of 245 patients with morphea. SETTING University of Texas Southwestern Medical Center-affiliated institutions. Patients Patients with clinical findings consistent with morphea. MAIN OUTCOME MEASURES Prevalence of concomitant au...

Background Disabling pansclerotic morphea is an extremely rare and severe disorder in children, systemic treatment with corticosteroids and methotrexate (MTX) or mycophenolate mofetil (MMF) are the most common therapies. However, patients can develop severe disabilities. Autologous stem cell transplantion (ASCT) is a successful treatment option for systemic scleroderma and might also be benefic...

BACKGROUND Radiation-induced morphea is a rare complication of radiation therapy. The affected areas are generally restricted to the radiation field or to the nearby surrounding area. CASE REPORT A 67-year-old Japanese woman with a history of right breast cancer followed by adjuvant radiotherapy was referred our hospital because of 7-year history of symmetrical indurated erythematous plaques ...

Morphea is an inflammatory skin condition leading to fibrosis of the and subcutaneous tissue which produces cosmetic functional impairment (FI). Few studies have systematically examined demographic clinical features morphea associated with FI, making it difficult stratify patients for screening FI based on risk. To address this gap, we performed a multicenter cross-sectional analysis adults chi...

sarcoidosis is multi organ disease with cutaneous manifestation in 20%-35% patients. cutaneous sarcoidosis has variable manifestations that make it difficult to diagnose. so clinical, histopathologic and laboratory evaluation is needed for diagnosis. most of cutaneous lesions presents as nodul, maculopapule and plaque. morpheaform lesion is a rare presentation of cutaneous sarcoidosis. this cas...

versa can also happen. However, the co-existence of a patch of morphea mimicking as Leprosy patch in an underlying case of neuriticleprosy, can be very misleading. We present a case with glove and stocking anaesthesia and peripheral nerve enlargement with a single large hypopigmented, non-anaesthetic macule on trunk, clinically diagnosed as Hansen's disease (Borderline Tuberculoid BT). Slit ski...

Morphea is a rare fibrosing disorder affecting the skin and underlying tissue. Also called localized scleroderma, morphea is characterized by lesions, which are initially erythematous or dusky violaceous patches eventually turning into hypopigmented sclerotic plaques with a typical lilac-coloured border. Generalized morphea is a rare subtype of morphea characterized by more than four le-sions o...