BACKGROUND Postoperative pain is one of the most common problems after hernia repair. Decrease in postoperative pain accelerates functional recovery, decreases duration of hospital stay and postoperative morbidity. OBJECTIVES To compare postoperative analgesic effect of infiltration of magnesium versus bupivacaine into incision of inguinal hernia repair. PATIENTS AND METHODS In a double bli...

The toxic effects of morphine sulfate in the adult cerebral cortex and one-day neonatal cerebellum have been studied. This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on the Purkinje cells and cerebellar cortical layer in 18- and 32-day-old mice offspring. Thirty female mice were randomly allocated into cases and controls. I...

Opiates have complex effects on seizure thresholds as these substances have both anti and proconvulsive actions in the mammalian brain. A reduction of inhibitory synaptic activity or enhancement of excitatory synaptic activity would be expected to trigger a seizure. This study is designed to determine how morphine and naloxone affect seizures induced by a low Mg2+ perfusate in the whole, intact...

objective: to compare the analgesiceffects of nitrous oxide and morphine sulfate in patients with acute renal colic due to urolithiasis. m e t h od s : this  was randomized clinical trial being performed in imam hossein hospital affiliated with shahid beheshti university  of medical sciences during a 1-year period from may2013 to may2014.  a  total of number of 100 patients, with an age range o...

R.J. KATZ, A CTH~_l o antagonism of morphine-induced behavioral activation in the mouse, European J. Pharmacol. 53 (1979) 383--385. The 4-10 fragment of adrenocort icotrophic hormone (ACTH4_10; Met-Glu-His-Phe-Arg-Trp-Gly) was administered intracerebroventricularly to C57B1 mice with and without concurrent systemic injection of a standard dose of morphine sulfate. Morphine produced s tereotyped...

the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed s...

Adult male Swiss-Webster mice of varying group size (single, or in groups of 2, 3, or 4) were injected with vehicle, or 2.5 or .50mg/lcg of morphine sulfate. In comparison with vehicle, morphineinjected mice showed heightened behavioral activity consisting mainly of stereotyped forward locomotion. This motor response was disproportionately enhanced by the presence of conspecifics. This suggests...

OBJECTIVE To evaluate the pain level in patients treated with epidural infusion of morphine sulfate in a single dose, after a surgical procedure to perform lumber arthrodesis. METHODS Forty patients underwent posterolateral lumbar arthrodesis or intersomatic lumbar arthrodesis via a posterior route at one, two or three levels. They were prospectively randomized into two groups of 20. In the f...

Background: Tolerance and dependence to anti-nociceptive effect of morphine restricted its use. Nowadays co-administration of morphine and other drugs suggests diminishing this tolerance. Baclofen is one of the drugs that may be beneficial in the attenuation of tolerance to morphine. Studies have shown that changes in transient receptor potential vanilloid type 1 (TRPV-1) expression during admi...

previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. opiate and cigarette have been used concomitantly as drug abuse. the aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. all experiments wer...