BACKGROUND Although epidermal growth factor receptor (EGFR), v-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer (NSCLC) were thought to be mutually exclusive, some tumors harbor concomitant mutations. Discovering a driver mutation on the basis of morphologic features and therapeutic responses with mutation analysis c...

conclusion non-mass-like lesions, lesions with focal or segmental distribution, with a “plateau” enhancement curve type were the most frequent findings of dcis lesions on mri. background adequate diagnosis of ductal carcinoma in situ (dcis) could lead to efficacious treatment. due to the fact that dcis lesions can progress to invasive carcinomas and that the sensitivity of the standard examinat...

Hypertrophic cardiomyopathy is a disease of cardiac muscle that is often genetically transmitted as. an autosomal dominant trait and is characterized by a wide variety of patterns of left ventricular hypertrophy that may be identified with wide-angle, two-dimensional echocardiography. To determine the degree to which left ventricular morphology is similar in related patients with hypertrophic c...

Paired samples of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) and the subsequent diffuse large cell lymphoma (DLL) of six cases of Richter's syndrome were investigated to establish the clonal relationship between the CLL/SLL and the DLL components and to define the oncogene and/or tumor-suppressor gene alterations involved in the morphologic transformation of CLL/SLL....

Hypertrophic cardiomyopathy is a disease of cardiac muscle that is often genetically transmitted as. an autosomal dominant trait and is characterized by a wide variety of patterns of left ventricular hypertrophy that may be identified with wide-angle, two-dimensional echocardiography. To determine the degree to which left ventricular morphology is similar in related patients with hypertrophic c...

Drug-induced liver injury presents with extremely diverse histologic patterns, including necroinflammatory, cholestatic, steatotic and vascular patterns. Sinusoidal obstruction syndrome (SOS), also referred to as toxic sinusoidal injury, veno-occlusive disease or “blue liver syndrome”, is a commonly recognized vascular pattern of drug-induced liver injury, and has been frequently associated wit...

Dermoscopy reveals structures and features invisible to the naked eye, providing additional morphologic information during clinical examination of skin lesions. This diagnostic technique was utilized in the detection of melanoma and other tumors [1]. More recently, utility of dermoscopy has expanded to inflammatory and infective conditions where vascular alterations, color variegations and foll...

Metastatic carcinomas involving the lung are a common specimen encountered in surgical pathology. These metastases may have different morphologic, and architectural patterns and may mimic primary pulmonary adenocarcinoma, especially the intra-alveolar (lepidic) pattern of spread which may simulate a primary pulmonary bronchioloalveolar carcinoma (adenocarcinoma in situ). We present the case of ...

Preputial gland neoplasms in the Fischer 344 rat are relatively uncommon tumors with a prevalence of approximately 3% in the National Toxicology Program data base. They occur late in life, are well differentiated, and rarely metastasize. Based on studies through 4 serial passages, 10 well-differentiated preputial gland neoplasms transplanted into the mammary fat pads of syngeneic recipients gre...