Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram-negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU-N44, was investigated against Enterobacter aerogenes by using fluorescent dyes to evaluate outer-membrane depolarization and permeabilization. Its...

background & aim: the aim of this clinical trial study was to evaluate sleep quality in patients with chronic lung disease and the role of controlled breathing to improve the quality of sleep. methods & materials: sixty-four patients with chronic lung disease in two group (experimental and control group) enrolled in a 7 weeks. before interventions, the pittsburgh sleep quality index (psqi) and ...

Purpose: Physiological changes during pregnancy impose numerous changes on the respiratory system that can affect the health of both mother and fetus. Regarding the importance of the normal breathing in the health of mother and fetus, this study aimed to investigate the effect of breathing exercise on breathing pattern of pregnant women.  Methods: The study population was pregnant women...

Shared parasites can strongly influence the outcome of competition between congeneric, sympatric hosts, and thus host population dynamics. Parasite-mediated competition is commonly hypothesized as an important factor in biological invasion success; invasive species often experience lower infection levels and/or parasite-induced mortality than native congeneric hosts. However, variation in infec...

Ora et labora: the Benedictine motto unfurls on the banderole of the title-page of William Harvey’s masterful Exercitatio anatomica de motu cordis et sanguinis in animalibus (1628). This monastic motto, ‘‘Pray and work’’, seems an odd advertisement for an anatomy book. Harvey submitted his manuscript for publication to William Fitzer in Frankfurt, who commissioned it to one of the eight printer...

MOTIVATION Abundance profiling (also called 'phylogenetic profiling') is a crucial step in understanding the diversity of a metagenomic sample, and one of the basic techniques used for this is taxonomic identification of the metagenomic reads. RESULTS We present taxon identification and phylogenetic profiling (TIPP), a new marker-based taxon identification and abundance profiling method. TIPP...

background and objective: the main causes of nocturnal hypoxemia are pulmonary diseases or sleep related breathing disorders. in overlap syndrome, the co-existence of chronic obstructive pulmonary disease (copd) and ob-structive sleep apnea (osa), blood oxygen alteration, and hypercapnia may be more severe. we aimed to study hypox-emia markers in osa patients with or without copd. materials and...