Modulation of voltage-activated Ca channels by adenosine was investigated in male rat major pelvic ganglion (MPG) neurons by using the whole-cell variant of the patch-clamp technique. Adenosine inhibited high voltage-activated (HVA) Ca currents in a concentration-dependent manner with an EC50 of 313 nM and a maximal inhibition of 36%, respectively. Inhibition of HVA Ca currents in adrenergic an...

Abstract Atomically monodispersed heterogeneous catalysts with uniform active sites and high atom utilization efficiency are ideal catalytic materials. Designing such type of catalysts, however, remains a formidable challenge. Herein, using wet-chemical method, we successfully achieved mesoporous graphitic carbon nitride (mpg-C 3 N 4 ) supported dual-atom Pt 2 catalyst, which exhibited excellen...

Bladder and erectile dysfunction are common urologic complications of diabetes and are associated with reduced parasympathetic autonomic control. To determine whether disruption of ganglionic neurotransmission contributes to the loss of function, we investigated synaptic transmission at parasympathetic, major pelvic ganglion (MPG) neurons in control and chronically (20 wk) diabetic mice. In con...

We investigated sweet-bitter and umami-bitter mixture taste interactions by presenting sucrose or umami stimuli mixed with quinine hydrochloride (QHCl) while recording single-unit activity of neurons in the parabrachial nucleus (PbN) of urethane-anesthetized C57BL/6J mice. A total of 70 taste-responsive neurons were classified according to which stimulus evoked the greatest net response (36 suc...

BACKGROUND The pathological complete response of neoadjuvant chemotherapy for breast cancer correlates with the prognosis for survival. Tumors may have different prognoses according to their molecular subtypes. This study was performed to evaluate the relevance of the pathological response and prognosis following neoadjuvant chemotherapy in the molecular subtypes of breast cancer. METHODS A c...

BACKGROUND Advanced stage cancer treatments are often invasive and painful-typically comprised of surgery, chemotherapy, and/or radiation treatment. Low transport efficiency during systemic chemotherapy may require high chemotherapeutic doses to effectively target cancerous tissue, resulting in systemic toxicity. Nanotherapeutic platforms have been proposed as an alternative to more safely and ...

Novel simple kinetic spectrophotometric method for the determination of tiopronin [N-(2mercaptopropionyl)-glycine, MPG] in pharmaceutical formulation has been developed and validated. The proposed method is based on the coupled redox-complexation reaction whose first step is reduction of Fe by MPG, while second one includes the complexation of Fe, resulted from preceding redox reaction, with 2,...

Normal adult male Swiss albino mice, weighing 25 g on the average, were exposed to 500 R gamma rays from a Cobalt-60 source in the presence and absence of the chemical MPG or 2 mercaptopropionyiglycine and histological studies of thymus were conducted at various post irradiation intervals. It was found that MPG, when given 30 minutes before irradiation, protected the thymus tissue and caused an...

A turn-on fluorescence sensor, Cu(2+)-c-mpg-C(3)N(4), was developed for detection of CN(-) in aqueous solution by simply mixing cubic mesoporous graphitic carbon nitride (c-mpg-C(3)N(4)) and aqueous solution of Cu(NO(3))(2). The highly sensitive detection of CN(-) with a detection limit of 80 nM is not only possible in aqueous solution but also in human blood serum.