A patient with neurofibromatosis type 1 was found to have an enhancing lesion in the cerebellum. Proton MR spectroscopy was performed and showed findings similar to those seen in healthy volunteers. A 3-year follow-up MR study showed the lesion was unchanged. Proton MR spectroscopy might prove useful in the diagnosis of hamartomas.

In this report, we describe the findings of diffusion MR imaging and proton MR spectroscopy in two infants with acute necrotizing encephalopathy in which there was characteristic symmetrical involvement of the thalami. Diffusion MR images of the lesions showed that the observed apparent diffusion coefficient (ADC) decrease was more prominent in the first patient, who had more severe brain damag...

Signals from intermolecular double-quantum coherences (iDQCs) have been shown to be insensitive to macroscopic field inhomogeneities and thus enable acquisition of high- resolution MR spectroscopy in the presence of large inhomogeneous fields. In this paper, localized iDQC (1)H spectroscopy on a whole-body 3-T MR scanner is reported. Experiments with a brain metabolite phantom were performed to...

S.K. Yadav S. Saksena Anshu Srivastava Arti Srivastava V.A. Saraswat M.A. Thomas R.K.S. Rathore R.K. Gupta BACKGROUND AND PURPOSE: MR imaging and H-MR spectroscopy changes are well reported in cirrhotic patients, whereas they are inadequately reported in EHPVO. The aim of this study was to investigate age-related changes in brain MR imaging and metabolite profile in EHPVO with and without MHE a...

A case of Marchiafava-Bignami disease was serially evaluated with MR imaging and MR spectroscopy at 1, 2, 4, and 11 months after the onset of symptoms. The first MR imaging study showed extensive abnormal signal intensity of the corpus callosum without macroscopic changes; a diagnosis of Marchiafava-Bignami disease was made, and vitamin therapy was initiated. Follow-up studies showed progressiv...

BACKGROUND AND PURPOSE Pentobarbital is known to affect cerebral metabolism; pentobarbital sedation is, however, frequently used for MR imaging and MR spectroscopy, especially in children. Accurate assessment of the brain metabolite levels is important, particularly in neonates with suspected brain injury. We investigated whether pentobarbital sedation has any effect on the ratios of spectral m...

On clinical MR systems the proton is the most widely used nucleus for applications of magnetic resonance spectroscopy (MRS). The widespread biological applications of 1 H-MRS cannot be covered in detail, but exemplary uses will be discussed or referred to. Clinical applications fall into two categories: clinical research vs. clinical routine, where the former primarily aims at average responses...

We analyzed the MR findings of five patients with benign intracranial epithelial tumors, commonly called epidermoids. The neoplasms were categorized into two groups on the basis of T1-weighted MR signal intensity (relative to brain): high-signal-intensity masses (short T1) and low-signal-intensity masses (long T1). Surgical specimens were obtained and analyzed by means of 13C MR spectroscopy. E...

Nuclear magnetic resonance spectroscopy (MRS) has been in use in biochemistry labs for more than 50 yr. In its earlier years, it was used primarily for in vitro chemical analysis of small samples. Magnetic resonance imaging (MRI) is a powerful imaging technique that combines exquisite sensitivity to soft tissue contrast with the ability to demonstrate anatomy in many different planes and projec...

BACKGROUND AND PURPOSE In this study, intensive video electroencephalogram (EEG) monitoring, high-resolution MR imaging (MR imaging), proton MR spectroscopy ((1)H-MR spectroscopy) and single-photon emission CT (SPECT) were compared in patients with temporal lobe epilepsy (TLE) to evaluate lateralization of affected hemisphere with regard to bilateral affection and postoperative outcome. PATIE...