Mesenchymal stem cells (MSC) have pushed the field of cell-based therapies by inducing tissue regeneration, immunosuppression, and angiogenesis mainly through vesicles soluble factors release (paracrine signaling). MSC-extracellular (MSC-EV) adaptable secretome homing to injured sites allowed researchers unlock a new era cell-free based therapy. In parallel, nanoparticles (NP) been explored in ...

For any generalized linear model, the Pearson goodness of fit statistic is the score test statistic for testing the current model against the saturated model. The relationship between the Pearson statistic and the residual deviance is therefore the relationship between the score test and the likelihood ratio test statistics, and this clarifies the role of the Pearson statistic in generalized li...

One-way analysis of covariance is a popular and common statisticalmethod, wherein the equality of the means of several random variables whichhave a linear relationship with a random mathematical variable, is tested. Inthis study, a method is presented to improve the one-way analysis of covari-ance when there is an uncertainty in accepting the statistical hypotheses. Themethod deals with a fuzzy...

Market microstructure noise is a challenge to high-frequency based estimation of the integrated variance, because the noise accumulates with the sampling frequency. This has lead to widespread use of constructing the realized variance, a sum of squared intraday returns, from sparsely sampled data, for example 5or 15minute returns. In this paper, we analyze the impact of microstructure noise on ...

Abstract Introduction There remains a paucity of novel therapeutics for limb salvage in patients with critical ischemia (CLI) whom revascularization procedures have failed and amputation is imminent. We shown that E-selectin+/Mesenchymal Stem Cell (MSC) injections into the ischemic tissue CLI mouse model improves function. Thus, we sought to determine mechanism action E-selectin+/MSC’s pro-angi...