نتایج جستجو برای: mst1

تعداد نتایج: 453  

2013
Takashi Tomiyama Yoshihiro Ueda Tomoya Katakai Naoyuki Kondo Kazuichi Okazaki Tatsuo Kinashi

Although the cell-to-cell contact between CD4(+)Foxp3(+) regulatory T (Treg) and their target cells is important for the suppressor function of Treg cells, the regulation of this process is not well understood. Here we show that the Mst1 kinase plays a critical role in the suppressor function of Treg cells through regulation of cell contact dependent processes. Mst1 (-/-) Treg cells failed to p...

2017
Ligen Shi Jianwei Lei Hangzhe Xu Jingwei Zheng Yan Wang Yucong Peng Jun Yu Jianmin Zhang

BACKGROUND Hydrogen sulfide (H2S) has shown a neuroprotective role in several cerebrovascular diseases. This study aimed to explore the underlying mechanisms of H2S in early brain injury after subarachnoid hemorrhage (SAH). METHODS One hundred seventy-seven male Sprague-Dawley rats were employed in this study. Sodium hydrosulfide (NaHS), a donor of H2S, was injected intraperitoneally at 60 mi...

Journal: :The International journal of developmental biology 2013
Susumu Nejigane Shuji Takahashi Yoshikazu Haramoto Tatsuo Michiue Makoto Asashima

Hippo signaling is a conserved pathway that regulates cell proliferation and organ size control. Mst1 and Mst2 were identified as homologs of hippo and as core kinases of the Hippo pathway in mammals. Here, we have characterized the role of Mst1 and Mst2 during Xenopus primitive hematopoiesis. We showed that Mst1 and Mst2 were strongly expressed in the Xenopus ventral blood island, where primit...

2017
Abigail Robertson Tamer M.A. Mohamed Zeinab El Maadawi Nicholas Stafford Thuy Bui Dae-Sik Lim Elizabeth J. Cartwright Delvac Oceandy

Adult fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSC) for use in various applications. However, there are challenges in iPSC generation including low reprogramming efficiency, yield, cell survival and viability. Since the Hippo signalling pathway is a key pathway involved in regulating cell proliferation and survival, we here test whether modification of the Hippo pat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Hai Song Kinglun Kingston Mak Lilia Topol Kangsun Yun Jianxin Hu Lisa Garrett Yongbin Chen Ogyi Park Jia Chang R Mark Simpson Cun-Yu Wang Bin Gao Jin Jiang Yingzi Yang

Control of organ size by cell proliferation and survival is a fundamental developmental process, and its deregulation leads to cancer. However, the molecular mechanism underlying organ size control remains elusive in vertebrates. In Drosophila, the Hippo (Hpo) signaling pathway controls organ size by both restricting cell growth and proliferation and promoting cell death. Here we investigated w...

Journal: :The EMBO journal 2009
Koko Katagiri Tomoya Katakai Yukihiko Ebisuno Yoshihiro Ueda Takaharu Okada Tatsuo Kinashi

The regulation of lymphocyte adhesion and migration plays crucial roles in lymphocyte trafficking during immunosurveillance. However, our understanding of the intracellular signalling that regulates these processes is still limited. Here, we show that the Ste20-like kinase Mst1 plays crucial roles in lymphocyte trafficking in vivo. Mst1(-/-) lymphocytes exhibited an impairment of firm adhesion ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Jae Keun Lee Jin Hee Shin Sang Gil Hwang Byoung Joo Gwag Ann C McKee Junghee Lee Neil W Kowall Hoon Ryu Dae-Sik Lim Eui-Ju Choi

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Dominant mutations in the gene for superoxide dismutase 1 (SOD1) give rise to familial ALS by an unknown mechanism. Here we show that genetic deficiency of mammalian sterile 20-like kinase 1 (MST1) delays disease onset and extends survival in mice expressing the ALS-associate...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Hiroki Ono Toshihiro Ichiki Hideki Ohtsubo Kae Fukuyama Ikuyo Imayama Yasuko Hashiguchi Junichi Sadoshima Kenji Sunagawa

OBJECTIVE Apoptosis of vascular smooth muscle cells (VSMCs) is observed in chronic vascular lesions such as atherosclerotic plaques and is believed to contribute to the vascular remodeling process. Mst1 is a ubiquitously expressed serine/threonine kinase known to be activated in response to a wide variety of nonphysiological apoptotic stimuli. However, little is known of the physiological funct...

Journal: :Frontiers in microbiology 2016
Yoong-Kit Aw Kuan-Shion Ong Learn-Han Lee Yuen-Lin Cheow Catherine M. Yule Sui-Mae Lee

Emergence of antimicrobial resistance coupled with the slowdown in discovery of new antimicrobial compounds points to serious consequences for human health. Therefore, scientists are looking for new antimicrobial compounds from unique and understudied ecosystems such as tropical peat swamp forests. Over the course of isolating antimicrobial producing bacteria from North Selangor tropical peat s...

Journal: :Cell 2006
Maria K. Lehtinen Zengqiang Yuan Peter R. Boag Yue Yang Judit Villén Esther B.E. Becker Sara DiBacco Núria de la Iglesia Steven Gygi T. Keith Blackwell Azad Bonni

Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. MST1 phosphorylates FOXO proteins at a conserved site within ...

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