Metal-responsive transcription factor-1 (MTF-1) is a zinc finger protein conserved from mammals to insects. It mediates protection against heavy metal load by activating the expression of metallothionein and other genes. In Drosophila, MTF-1 serves a dual function in that it not only helps to protect against heavy metal load but also induces the expression of Ctr1B, the gene for an intestinal c...

We have previously reported that oxidative stimuli liberate Zn(2+) from metalloproteins, a phenomenon that can trigger neuronal cell death. Excessive intracellular Zn(2+) in many cell types triggers the expression of genes that encode metal binding proteins, such as metallothionein, via the activation and nuclear translocation of metal response element (MRE)-binding transcription factor-1 (MTF-...

The present study aimed to investigate differences in personality traits among male-to-female (MtF), female-to-male (FtM) gender identity disorder (GID) subjects and non-transsexual male (M) and female (F) controls. Subjects were 72 MtF and 187 FtM GID subjects without psychiatric comorbidities together with 184 male and 159 female non-transsexual controls. Personality traits were assessed usin...

Mai Tong Fang (MTF), a Chinese herbal combination, has been used for the treatment of diabetic nephropathy in traditional medical clinics in China. However, the anti-adipogenic and anti-hyperglycemic effects of MTF have not been fully elucidated, so this study explored these pharmacological activities in 3T3-L1 adipocytes and ob/ob mice, respectively, of the water fraction of milkvetch root, sa...

Metallothioneins (MTs) are small cysteine-rich proteins that bind heavy metal ions such as zinc, cadmium and copper with high affinity, and have been functionally implicated in heavy metal detoxification and radical scavenging. Transcription of metallothioneins genes is induced by exposure of cells to heavy metals. This induction is mediated by metal-responsive promoter elements (MREs). We have...

A new Chinese herbal formula called Mai Tong Formulae (MTF) has recently been used to treat lower limb macroangiopathy in type 2 diabetes mellitus (T2DM) patients. In this study, we investigated the effect of MTF on lower limb macroangiopathy in a spontaneous diabetic rat model (GK rats). We found that MTF treatment significantly reduced serum fasting blood glucose (FBG), triglycerides (TG), to...

The modulation transfer function (MTF) is widely used to describe the spatial resolution of x-ray imaging systems. The MTF is defined to have a zero-frequency value of unity, and it is common practice to ensure this by normalizing a measured MTF curve by the zero-frequency value. However, truncation of the line spread function (LSF) within a finite region of interest (ROI) results in spectral l...

This paper proposes a wire electrical discharge machining (WEDM) product quality prediction method, called MTF-CLSTM, to integrate the Markov transition field (MTF) and convolutional long short-term memory (CLSTM) neural network. The proposed MTF-CLSTM method can accurately predict WEDM workpiece surface roughness right after manufacturing by collecting analyzing static parameters dynamic condi...

Purpose The aim of this study was to evaluate the effect residual astigmatism on postoperative visual outcomes after trifocal intraocular lens implantation. Methods In prospective observational study, we divided 156 eyes into two groups according measured by subjective optometry and followed them up for 3 months. Visual acuity, modulation transfer function (MTF) curves, Strehl ratio (SR), Funct...