The PathfinderTG biomarker panel is useful in the evaluation of pancreatic cysts that have clinical features suspicious for malignancy, but its utility in classifying fine-needle aspiration biopsies from small pancreatic cystic lesions is yet to be proven. We used morphology to classify 20 pancreatic cyst cytology aspirates, all of which met radiographic criteria for close observation. Cases we...

Cystic lesions of the pancreas are increasingly recognized. While some lesions show benign behaviour (serous cystic neoplasm), others have an unequivocal malignant potential (mucinous cystic neoplasm, branch- and main duct intraductal papillary mucinous neoplasm and solid pseudo-papillary neoplasm). European expert pancreatologists provide updated recommendations: diagnostic computerized tomogr...

Kras mutation is a common phenomenon in many human neoplasms. We aimed to assess the Kras mutational status along the histological continuum from normal ovaries to the development of benign, borderline and malignant ovarian mucinous neoplasms. We analyzed 41 cases of malignant, 10 cases of borderline, 7 cases of benign mucinous ovarian tumors and 7 cases of normal ovarian tissue. The prevalence...

Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clea...

Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes. The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. The candidate genes with mucinous hist...

Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovaria...

Primary mucinous adenocarcinoma of renal pelvis is a rare cystic neoplasm which mimics a hydronephrosis or pyonephrosis radiologically. We are presenting here a case report where mucinous cystadenocarcinoma of pelvicalyceal system was mimicking clinically and radiologically as pyonephrosis but diagnosed preoperatively through a simple and rapid test, Ultrasoundguided fine-needle aspiration cyto...

Primary mucinous adenocarcinoma of renal pelvis is a rare cystic neoplasm which mimics a hydronephrosis or pyonephrosis radiologically. We are presenting here a case report where mucinous cystadenocarcinoma of pelvicalyceal system was mimicking clinically and radiologically as pyonephrosis but diagnosed preoperatively through a simple and rapid test, Ultrasoundguided fine-needle aspiration cyto...

Mucinous lesions of the breast represent a broad spectrum of entities, which may pose a diagnostic challenge on fine-needle aspiration cytology. Mucinous carcinomas are so bland cytologically that they may be misdiagnosed as benign lesions, especially in cellpoor samples with ample mucin [1]. Assessment of cytologic details in conjunction with the radiological and clinical findings leads to a m...