Pancreatic ductal adenocarcinoma (and its histological variants), also referred to as pancreatic cancer (PC) comprises 90% of exocrine pancreatic neoplasms [1]. This highly aggressive cancer is the fourth leading cause of cancer death in the USA [2]. More than 80% of patients with PC present with advanced disease that is incurable by surgery. Most tumors greater than 5 cm in size show dissemina...

BACKGROUND Management of pancreatic cysts is based on neoplastic-nonneoplastic discrimination. Endoscopic ultrasound (EUS) enables to differentiate neoplastic-nonneoplastic lesions and also allows fine-needle aspiration (FNA). In this study, we aim to assess feasibility and clinical relevance of cytological and biochemical analysis in differential diagnosis of cystic pancreatic lesions in patie...

Context. One of the characteristic findings of intraductal papillary mucinous neoplasms (IPMN) is the presence of a direct communication between the lesion and the ductal pancreatic system and when magnetic resonance cholangiopancreatography (MRCP) shows uncertain findings, it is useful to perform a MRCP after secretin stimulation (MRCP-S) which provides a better visualization of the ductal sys...

Pancreatic cysts that develop after abdominal trauma are generally considered to be pseudocysts. We present a patient with a post-traumatic peri-pancreatic cyst that later ruptured suddenly, leading to an acute abdomen. Following an urgent laparotomy and excision of the cyst, post-operative histopathological assessment showed this to be a mucinous cystadenoma of the pancreas. We have reviewed t...

AIMS To evaluate postoperative morbidity and mortality, pancreatic function and long-term survival in patients with surgically treated pancreatic or periampullar tumours. PATIENTS AND METHODS Cohort study including 160 patients consecutively operated on: 80 pancreaticoduodenectomies (PD), 30 distal pancreatectomies (DP), 7 total pancreatectomies, 4 central pancreatic resections and 3 ampullec...

Ovarian adenofibroma is a rare benign tumour originating from the germinal lining and stroma of the ovary. We describe here the case of a 36-year-old woman with an ovarian mucinous cystadenofibroma that was diagnosed as a benign cystic mass of the ovary before surgery. The tumour was a cystic lesion composed of 2 regions: one filled with mucinous fluid and the other with yellowish solid compone...

Among 31 benign cystic neoplasms of the pancreas diagnosed as mucinous cystadenomas, we identified 9 (29%) cases of nonmucinous cystadenomas with a pancreatobiliary phenotype and an ovarian-like stroma. Although both cystic tumors belong to the same family, they should be separated because their epithelial lining and cyst fluid are different. The lining cells of the nonmucinous cystadenomas con...

We retrospectively investigated the incidence of pancreatic ductal adenocarcinoma among patients with intraductal papillary mucinous neoplasms of the pancreas. Based on imaging in 195 such patients, we chose surgery as initial treatment for 54, and periodic evaluation over 6 to 192 months (mean, 52) for 141. In 6 of the 141 patients observed for intraductal papillary mucinous neoplasm (4.2%), p...

The World Health Organization (WHO) classification of cystic pancreatic tumors defines mucinous cystic neoplasms as large, thick-walled, septated cysts with no communication with the main pancreatic duct, associated with the presence of ovarian-like stroma. Serous cystic neoplasms, on the contrary, present with a cuboidal or simple squamous epithelium and fibrous or hyalinized stroma without ov...

Cystic pancreatic neoplasms comprise a heterogeneous group of pathologic entities. Mucinous cystic tumors and serous cystadenomas account for more than 75% of reported cases. While serous cystadenomas are almost uniformly benign, mucinous cystic tumors all have malignant potential and must be treated as such. While both clinical and biochemical features can distinguish among the various cystic ...