OBJECTIVE A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown. In this study, HA117 gene was investigated whether it could increase the drug resistance in chronic myelogenous myeloid leukemia cell line K562. METHODS HA117 was cloned and adenovirus vectors were con...

All-trans retinoic acid (ATRA) induces complete remission in almost all patients with acute promyelocytic leukemia (APL) via its ability to induce the in vivo differentiation of APL blasts. However, prolonged ATRA treatment can result in drug resistance. In previous studies, we generated a multi-drug-resistant HL60/ATRA cell line and found it to contain a new drug resistance-related gene segmen...

One of the most important challenges in fight against cancer is acquired drug resistance. P-glycoprotein (P-gp), encoded by ABCB1 gene many organs, one factors involved development P-gp mainly efflux toxic substances such as xenobiotics from cell. In addition to these, it also plays a role drugs used treatment cancer, rate success reduces. Phenolic compounds are chemicals that naturally synthes...

To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targete...

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid inEscherichia colidepend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% o...

conclusions: our findings suggest the possible co-carriage of some blashv genes and aris on the same plasmids harboring the mdr genes. possible role of integrons in dissemination of esbl-encoding blashv genes among esbl-producing k. pneumoniae nosocomial isolates may be inferred. background: some genetic and phenotypic variables are associated among distinct microbial populations. objectives: t...

Multi-drug resistant bacteria are a public health problem associated with high morbidity and mortality globally. This increasing drug resistance has been linked to gene exchange between bacteria. Integrons systems known play significant role in the acquisition dissemination of antimicrobial genes especially Gram negative Hence, this study aims evaluate integrons members Enterobacteriaceae obtai...

Introduction: Pseudomonas aeruginosa is an opportunistic pathogen of clinical importance, particularly in immunocompromised and burn patients. This bacterium is becoming resistant to many antibiotics via intrinsic or acquired mechanisms. Mutations in anti-mutator genes, such as pfpI, can be a potential intrinsic mechanism of antibiotic resistance. This study aimed to evaluate the possible effec...