We review our baboon models of Escherichia coli sepsis that mimic, respectively, the shock/disseminated intravascular coagulation (DIC) and organ failure variants of severe sepsis, and analyse the pathophysiologic processes that are unique to each. The multi-stage, multi-factorial characteristics of severe sepsis develop as a result of the initial insult, which - depending on its intensity - ac...

There is no doubt that ionising radiation damages DNA and that certain organs in the body are more vulnerable than others to the effects of radiation. However, the reasons for the different sensitivities vary and there are now known to be many late expressed effects of exposure that cannot simply be explained on the basis of direct DNA damage. Examples include transmissible genomic instability,...

long-term mechanical circulatory support is a life-saving technology while briding to heart transplantation. it increases the quality of life and preserves end-organ function for patients with  advanced heart failure. the number of patients with advanced heart failure scheduled for heart transplantation before comorbidities escalate is on the rise. however, the device function is complicated by...