Whole-body combined PET/MR imaging has found its way into clinical practice recently and has opened up new possibilities for multiparametric morphologic and functional imaging [1]. The first PET/MR studies identified clinical applications where PET/MRI as a combined modality may have advantages over the established modalities of PET/ CT and MRI, e. g., CNS imaging [2], local prostate imaging [3...

The effects of enzalutamide monotherapy on prostate tumor downsizing and multiparametric MRI are currently unknown. Here we present the first case in literature of a patient with high-grade prostate cancer who underwent 3 months of neoadjuvant enzalutamide, for which the effects on mpMRI and histology were determined. Tumor size reduction and downstaging were noted. Neoadjuvant enzalutamide res...

The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo ...

OBJECTIVE The purpose of this diagnostic meta-analysis was to determine the diagnostic accuracy of multiparametric MRI for prostate cancer detection using anatomic T2-weighted imaging combined with two functional techniques: diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI). MATERIALS AND METHODS We searched electronic databases, including MEDLINE, Embase, and the C...

In their comprehensive review of the state of the art of prostate MRI technology, Gupta et al do a masterful job of summarizing the technically complex subject of multiparametric MRI (mpMRI). The review is a good primer for anyone getting started in bringing mpMRI of the prostate to his or her institution. However, while the “what” of mpMRI is well covered; we would like to use this space to ex...

In the ongoing effort to understand and cure prostate cancer, imaging modalities are constantly evolving to assist in clinical decisions. Multiparametric MRI can be used to direct prostate biopsies, improve diagnostic yield, and help clinicians make more accurate decisions. PET is superior in providing biologic information about the cancer and is sensitive and highly specific. Integrated PET/MR...

Key Learning Points: 1) Currently the most valuable and practical MpMRI protocol consists of T2WI, DWI and DCE. 2) Significant and additive improvement in the predictive values for prostate cancer detection, especially in the PZ, is achievable when combinations of the imaging strategies are combined. 3) Information from MpMRI can be used to direct and increase the yield from prostate biopsies. ...

Multifunctional magnetic resonance imaging (MRI) techniques are increasingly being used to address bottlenecks in prostate cancer patient management. These techniques yield qualitative, semi-quantitative and fully quantitative biomarkers that reflect on the underlying biological status of a tumour. If these techniques are to have a role in patient management, then standard methods of data acqui...

PURPOSE Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating...

A. M. Weidner, H. J. Michaely, A. Lemke, L. Breitinger, M. S. Michel, F. Wenz, N. Schnitzer, S. O. Schönberg, and D. J. Dinter Department of Clinical Radiology and Nuclear Medicine, University Medical Center, Mannheim, Germany, Computer Assisted Clinical Medicine, University Medical Center, Mannheim, Germany, Mannheim, Germany, Department of Urology, University Medical Center, Mannheim, Germany...