As with pairwise alignment, multiple sequence alignments (MSAs) are typically scored by assigning a score to each column and summing over the columns. The most common approach to scoring individual columns in a multiple alignment is to calculate a score for each pair of symbols in the column, and then sum over the pair scores. This is called sum-of-pairs or SP-scoring. For global multiple seque...

BACKGROUND Early classification of severity of peritonitis by scoring systems, including the Mannheim peritonitis index (MPI) and the multiple organ failure (MOF) score, modulates surgical and medical management. AIM To predict outcome of patients with peritonitis using the MPI and MOF scoring systems. METHODS Prospective evaluation of the MPI and MOF score was performed in 80 consecutive p...

multiple sclerosis (ms) is an inflammatory disease of central nervous system (cns) and sexual dysfunction (sd) is one of the most common disabilities of ms women. the aim of this study was to determine sexual function of women with ms (multiple sclerosis). one hundred definite ms patients ms patients and fifty age-matched healthy controls were enrolled. demographic data (sex, age), duration of ...

OBJECTIVE To examine how different scoring models for a diet quality index influence associations with mortality outcomes. DESIGN A study within the Malmö Diet and Cancer cohort. Food and nutrient intakes were estimated using a diet history method. The index included six components: SFA, PUFA, fish and shellfish, fibre, fruit and vegetables, and sucrose. Component scores were assigned using p...

Sequence alignment algorithms have a long standing tradition in bioinformatics. In this paper, we formulate an extension to existing local alignment algorithms: local alignments across multiple scoring functions. For this purpose, we use the Waterman-Eggert algorithm for suboptimal local alignments as template and introduce two new features therein: 1) an alignment of two strings over a set of ...

Track-oriented multiple hypothesis tracking (MHT) is well-established as a paradigm for multi-sensor multitarget tracking. The fundamental approach includes many variants. Hypothesis-oriented MHT was first proposed by Reid [10]. The initial integer-programming formulation of the problem is due to Morefield [8]. The hybrid-state decomposition that allows for computationally-efficient track-orien...

How to align two given sequences properly is a fundamental problem in bioinformatics. In the sequence alignment problem, the most essential thing that directly affects the resulting alignment is the scoring matrix. There are a variety of scoring matrices used for alignment, and each of them has its own purpose in biosequence alignment. It seems unlikely that an alignment is optimal for each sco...

This study assessed the accuracy of a cardiorespiratory monitoring device versus polysomnography for the diagnosis of suspected sleep apnoea/hypoponea syndrome (SAS). A total of 86 patients (89% male, mean age 52 yrs) that had been referred to a sleep laboratory with a clinical diagnosis of SAS underwent cardiorespiratory polygraphy in an unattended mode using an ambulatory device (MERLIN). Ana...