BACKGROUND There is uncertainty as to which intake of vitamin D is needed to suppress PTH and maintain normal bone metabolism throughout winter at northern latitudes. We aimed to investigate whether four weeks' daily supplementation with 10 μg vitamin D3 from fish oil produced a greater change in serum vitamin D metabolites, parathyroid hormone, and bone turnover in healthy adults compared with...

Background Several recent reviews, based mainly on observational studies, have however identified that micronutrient concentrations in the peri-conception period influence female fertility and embryogenesis, and may prevent adverse pregnancy outcomes.The possible effects on subfertility of two micronutrients(Zinc and Selenium), Components of antioxidant enzymes which are commonly included in or...

OBJECTIVE To study the effect of periconceptional multivitamin supplementation on neural tube defects and other congenital abnormality entities. DESIGN Randomised controlled trial of supplementation with multivitamins and trace elements. SETTING Hungarian family planning programme. SUBJECTS 4156 pregnancies with known outcome and 3713 infants evaluated in the eighth month of life. INTER...

OBJECTIVE To investigate the effect of supplementation with multivitamin and mineral on blood pressure and C-reactive protein (CRP) in obese women with increased cardiovascular disease risk as having hypertension, hyperglycemia or hyperlipemia. SUBJECTS AND METHODS 128 obese Chinese women aged 18-55 years with increased cardiovascular disease risk participated in a 26-week randomized, double-...

AIMS To study the role of maternal employment status as indicator of socioeconomic status in the origin of isolated orofacial clefts (OFC) and in the use of periconceptional folic acid/multivitamin supplementation. METHODS 1,975 cases with OFC (1,374 cases with cleft lip +/- palate and 601 cases with posterior cleft palate), 38,151 population controls without any defects and 20,868 patient co...

The authors investigated a possible association of supplemental folic acid and multivitamin use with placental abruption by using data on 280,127 singleton deliveries recorded in 1999-2004 in the population-based Medical Birth Registry of Norway. Odds ratios, adjusted for maternal age, marital status, parity, smoking, pregestational diabetes, and chronic hypertension, were estimated with genera...