We report the case of a 62-year-old male patient with previous diagnosis myasthenia gravis who experienced myasthenic crisis due to lower respiratory tract infection caused by Burkholderia cepacia. The was admitted neuro-intensive care unit and received ventilatory support address insufficiency. Treatment included tigecycline piperacillin-tazobactam for suspected bacterial infection, as well ta...

Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission leading to generalized or localized muscle weakness due most frequently to the presence of autoantibodies against acetylcholine receptors in the postsynaptic motor end-plate. Myasthenic crisis (MC) is a complication of MG characterized by worsening muscle weakness, resulting in respiratory failure that require...

Sir, I read with interest the recent article by Murthy et al. It provides excellent data regarding the management and outcome of patients with myasthenic crisis. I would like to make certain observations. First, Murthy et al have utilized the neostigmine test for confirmation of diagnosis. I would like to emphasize that the edrophonium (Tensilon) test is an excellent alternative for this purpos...

Myasthenia gravis and Graves' disease are two autoimmune diseases with a similar mechanism, both having circulating organ autoantibodies and cell specific autoantibodies. It is not unusual for these diseases to occur together. There is a large body of data proving that antithyroid drugs such as methimazole and propylthiouracil have an immunomodulatory effect in addition to their thyrosuppressan...

Objective. To present a case of maternal myasthenia gravis in pregnancy and give a systematic review of the literature. Case. We report the case of a 38-year-old parturient with a life-threatening complication of immune-mediated myasthenia gravis shortly after an elective cesarean section on patient's request under spinal anesthesia at 35 + 3 weeks of gestation. The newborn was transferred to t...

BACKGROUND AND OBJECTIVE Myasthenic crisis is a life-threatening complication of myasthenia gravis (MG) and when treated aggressively is associated with good outcome. MATERIALS AND METHODS Retrospective study of case records of patients with episodes of myasthenic crisis. RESULTS Twenty-one (22%) of the 95 patients with MG (9 with thymoma), experienced 23 episodes of myasthenic crisis, 3 (3...