CONTEXT Current remission maintenance therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are limited by partial efficacy and toxicity. OBJECTIVE To compare the effects of mycophenolate mofetil with azathioprine on the prevention of relapses in patients with AAV. DESIGN, SETTING, AND PARTICIPANTS Open-label randomized controlled trial, International Mycophen...

mycophenolate mofetil (mmf) is a selective inhibitor of inosine-5′-monophosphate dehydrogenase. gastrointestinal (gi) disturbances in immature ones are reported for mmf-induced compilations, which in the case of occurrence dose reduction is required. thus, in the present study, the fructooligosaccharide raftilose® (rft) was co-administrated with mmf to estimate the protective effect of rft agai...

the subject of transplant immunosuppression has generated significant interest in recent years. excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. there is widespread support for the notion that the fundamental objective in transplant immunology should be the achievement of specific graft tolerance. ...

there are wide individual differences in pharmacokinetic parameters of mycophenolate mofetil (mmf) among transplanted patients. some studies have shown that single nucleotide polymorphisms (snps) of the uridine diphosphate glucuronosyl transferase1a9 (ugt1a9) are responsible for these differences in early days after transplantation. therefore it was decided to evaluate the influence of ugt poly...

Acquired pure red-cell aplasia is a rare disorder that can be either idiopathic or associated with certain autoimmune diseases, pregnancy, lymphoproliferative disorders, nutritional deficiencies, or medicines. We present a deceased-donor renal transplant patient who developed pure red-cell aplasia associated with mycophenolate mofetil or tacrolimus and was treated with cyclosporine. A 20-year-o...

The main treatment for pemphigus vulgaris are systemic corticosteroids and immunosuppressive agents, but due to adverse reactions and therapeutic failure, new drugs such as rituximab and mycophenolate mofetil have been used. In this case report are described two cases of severe pemphigus vulgaris refractory to various treatments, with resolution after use of rituximab and mycophenolate mofetil,...