نتایج جستجو برای: mylagic encephalomyelitis
تعداد نتایج: 11120 فیلتر نتایج به سال:
background and objectives: multiple sclerosis is an inflammatory disease of the central nervous system. this is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. however, liver has an anti-inflammatory microenvironment. myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...
Brain-derived neurotrophic factor plays a key role in neuronal and axonal survival. Brain-derived neurotrophic factor is expressed in the immune cells in lesions of experimental autoimmune encephalomyelitis and multiple sclerosis, thus potentially mediating neuroprotective effects. We investigated the functional role of brain-derived neurotrophic factor in myelin oligodendrocyte glycoprotein-in...
A specific complement fixation test can be obtained in various central nervous system virus infections by using as antigens emulsions of infected brain tissue, freezing and thawing the brain emulsion, and then centrifuging it in an angle head centrifuge at 3500 R.P.M. for 1 hour. The method has proved reliable in the case of rabies, St. Louis encephalitis, Japanese B encephalitis, lymphocytic c...
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin olig...
In previous communications we have reported the experimental production of encephalomyelitis in guinea pigs with some brain lipid extracts and brain residue (after lipid extraction with cold acetone, ether and alcohol), composed mostly of proteins (1). In the present report we shall record our observations on the production of experimental encephalomyelitis in guinea pigs with a protein calcium...
Progressive multiple sclerosis is associated with metabolic failure of the axon and excitotoxicity that leads to chronic neurodegeneration. Global sodium-channel blockade causes side effects that can limit its use for neuroprotection in multiple sclerosis. Through selective targeting of drugs to lesions we aimed to improve the potential therapeutic window for treatment. This was assessed in the...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an increasingly recognized disorder, particularly in children. Acute disseminated encephalomyelitis (ADEM) the most common presentation of paediatric MOGAD. Children with ADEM should always be evaluated for MOGAD, as appropriate and timely treatment may help improve long-term outcomes.
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