OBJECTIVES Myocardial fibrosis is a major component of ventricular remodeling after large myocardial infarction (MI). The present study tests the hypothesis that post-ischemic myocardial fibrosis can occur independent of hemodynamic changes. METHODS A mouse model of distal left coronary artery ligation was established to induce a small infarct (less than 15% of the left ventricle) in order to...

The objective of our study was to assess the influence of mechanical ventilation on healthy body organs. Fifteen piglets (aged 6 weeks, 19-27 kg) were anesthetized, instrumented, and divided into three groups: Group A - spontaneously breathing, group B - mechanically ventilated with tidal volume 6 ml/kg, and group C - ventilated with tidal volume 10 ml/kg for 12 hours. The parameters of lung, h...

Background—The relative merits of left ventricular (LV) dyssynchrony, LV lead position, and myocardial scar to predict long-term outcome after cardiac resynchronization therapy remain unknown and were evaluated in the present study. Methods and Results—In 397 ischemic heart failure patients, 2-dimensional speckle tracking imaging was performed, with comprehensive assessment of LV radial dyssync...

Background and Objective: Acute myocardial infarction (MI) is caused due to coronary artery occlusion and divided into two forms of ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction. This study aimed to determine the success rate of treatment with primary PCI (percutaneous coronary intervention) versus thrombolysis in the establishment of perfusion and to evaluate the sho...

Introduction: Myocardial perfusion imaging using gated SPECT and phase analysis is an effective tool in evaluation of mechanical dyssynchrony. The purpose of this study was to determine the normal ranges of global and regional phase parameters. Methods: A total of 100 patients with normal resting and stress electrocardiograms, low pretest likelihood for c...

objective: the study was conducted to evaluate cardioprotective effect of silk cocoon (abresham) bombyx mori (b. mori) on isoprenaline-induced myocardial infarction. this study deals with the cocoons, which is called abresham in the unani system of medicine. it is one of the 64 drugs which avicenna has mentioned in avicenna’s tract on cardiac drugs and used in the treatment of cardiovascular di...

Heart failure is a leading cause of death in New Zealand. In order to determine the causesof rhythm disturbances leading to failure a knowledge of the structure and mechanical behaviour of cardiac tissue is important. This paper presents realistic stress and strain distributions for the passive heart that have been reproduced using a three-dimensional finite element model of the ventricles base...

Contrast echocardiography has been proposed as an indicator of myocardial perfusion in a non-invasive way. Reperfusion curves can be obtained by destroying all the microbubbles using an ultrasound pulse with high mechanical index and acquiring images during the reperfusion process. Quantitative parameters describing the process can be obtained from the curves. To analyze the complete myocardium...

Objective: The study was conducted to evaluate cardioprotective effect of silk cocoon (Abresham) Bombyx mori (B. mori) on isoprenaline-induced myocardial infarction. This study deals with the cocoons, which is called Abresham in the Unani system of medicine. It is one of the 64 drugs which Avicenna has mentioned in Avicenna’s tract on cardiac drugs and used in the treatment of cardiovascular di...