نتایج جستجو برای: myokine
تعداد نتایج: 312 فیلتر نتایج به سال:
OBJECTIVE Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced myokine during mitochondrial disease and proposed as key metabolic mediator of the integrated stress response (ISR) presumably causing systemic metabolic improvements. Curiously, the precise cell-non-autonomous and cell-autonomous relevance of endogenous FGF21 action remained poorly understood. METHODS We ...
Diabetic peripheral neuropathy (DPN) remains one of the most common and serious complications of diabetes. Currently, pharmacological agents are limited to treating the pain associated with DPN, and do not address the underlying pathological mechanisms driving nerve damage, thus leaving a significant unmet medical need. Interestingly, research conducted using exercise as a treatment for DPN has...
Background Myokines are a group of protein mediators produced by skeletal muscle under stress or physical exertion. Even though their discovery and effects in cell culture and animal models of disease have elicited great enthusiasm, very little is known about their role in human metabolism. We assessed whether plasma concentrations of three known myokines [myonectin, myostatin, and fibroblast-d...
Background: Myokines released from skeletal muscle have multiple metabolic and hypertrophic effects. On the other hand, one of proposed pathways for effects of exercise training on metabolic diseases is calcineurin signaling pathway. With considering to relation between interleukin-6 (IL-6) and calcineurin, the purpose of this study was to investigate whether the resistance training has an effe...
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