Abstract Organic syntheses by adopting green protocols such as sonochemical procedures, microwave technologies, solvent-free conditions, solvent, heterogeneous catalysis particularly nanocatalysts, ionic liquids have replaced the traditional procedures due to concerns pertaining especially environment. The heterocycle, pyrazole, its multifaceted applications has been cyanosure of chemists and t...

A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were evaluated as potential inhibitors of alkaline phosphatases, namely human tissue non-specific alkaline phosphatase (h-TNAP) and tissue specific i...

1-[(N-acetyl)2,3-dichloroanilinomalonyl]3,5-dimethyl-4-(unsubstituted/substituted phenylazo) pyrazoles have been synthesised in 34 to 65% yield, by the reaction of 2,4-diketo-3(unsubstituted/substituted phenylazo) pentane with Ethyl-2-[(N-acetyl)2,3-dichloroanilido] acetohydrazide. Pyrazoles are brown and yellow colour solids, having high melting points. Identity of products has been establishe...

Several new bitopic pyrazole-containing ligands were prepared from the corresponding pyrazoles and tetrahalogen or tetratosyloxy derivatives of o-xylene and neopentane in a superbasic medium (KOH-DMSO).

A simple titanium complex catalyzes the coupling of alkynes, isonitriles, and monosubstituted hydrazines to generate substituted pyrazoles in a single step.

Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties. Herein, we report acid-catalyzed synthesis of a new tricyclic, trifluoromethylated indenopyrazole, 3-methyl-1-(4-(trifluoromethyl)phenyl)indeno[1,2-c]pyrazol-4(...