نتایج جستجو برای: n disubstituted diaminoglyoxime

تعداد نتایج: 978854  

Journal: :The Journal of the Society of Chemical Industry, Japan 1970

2014
Kurt S. Van Horn Xiaohua Zhu Trupti Pandharkar Sihyung Yang Brian Vesely Manu Vanaerschot Jean-Claude Dujardin Suman Rijal Dennis E. Kyle Michael Zhuo Wang Karl A. Werbovetz Roman Manetsch

A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular amastigotes. A structure-activity and structure-property relationship study was conducted in part using the Topliss operational scheme to identify new lead compounds. This study led to the identification of quinazolines with EC50 values in the...

Journal: :Chemical Science 2023

Herein, we report the first palladium/MPAA catalyzed enantioselective C-H activation/[4+1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use readily accessible mono N-protected amino acid...

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