The proposed article relates to organic chemical synthesis and the study of bis-azourea compounds, properties new N,N1 derivatives - hexamethylene bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino) ureas]. interaction [(4,41-dimethyldiphenyl)-azo-2,21-diamino)-urea] with diisocyanate gave structure bis-[(4,41-dimethyldiphenyl)-azo-2,21-diamino)urea] was established by elemental analysis, IR PMR spe...

Ubiquitylation is a covalent post-translational modification that regulates protein stability and is involved in many biological functions. Proteins may be modified with mono-ubiquitin or ubiquitin chains. Viruses have evolved multiple mechanisms to perturb the cell ubiquitin system and manipulate it to their own benefit. Here, we report ubiquitylation of vaccinia virus (VACV) protein N1. N1 is...

We used human electroencephalogram to study early audiovisual integration of dynamic angry and neutral expressions. An auditory-only condition served as a baseline for the interpretation of integration effects. In the audiovisual conditions, the validity of visual information was manipulated using facial expressions that were either emotionally congruent or incongruent with the vocal expression...

Biofilm communities cultivated in rotating annular bioreactors using water from the South Saskatchewan River were assessed for the effects of seasonal variations and nutrient (C, N, and P) additions. Confocal laser microscopy revealed that while control biofilms were consistently dominated by bacterial biomass, the addition of nutrients shifted biofilms of summer and fall water samples to photo...

Notch1 (N1) receptor signaling is essential and sufficient for T cell development, and recently developed in vitro culture systems point to members of the Delta family as being the physiological N1 ligands. We explored the ability of Delta1 (DL1) and DL4 to induce T cell lineage commitment and/or maturation in vitro and in vivo from bone marrow (BM) precursors conditionally gene targeted for N1...

This paper examines maturational changes in the spatiotemporal features of central and lateral N1 components of the auditory evoked potentials (AEPs) to tone stimuli presented with a long stimulus onset asyncrony (SOA; 4200 ms) using the scalp current density (SCD) technique. A group of typically developing children ranging from 6 to 12 years of age and a group of adults were studied. Recently ...

A conserved positive-acting RNA sequence was found to be required for the neuron-specific splicing of the mouse c-src N1 exon. The sequence lies in the intron between exons N1 and 4, close to the N1 donor site. Normally, only the neural-specific splicing of exon N1 required this sequence. When the intron downstream of N1 was shortened, splicing at the constitutive exon 4 acceptor also became de...

Objectives: Children’s auditory event-related potentials (ERPs) are dominated by the P1 and N2 peaks, while the N1 wave emerges between 3 and 4 years of age. The neural substrates and the behavioral correlates of the protracted N1 maturation, as well as of the 10-year long predominance of the N2 are unclear. The present study utilized high-resolution electroencephalography to study the maturati...

Let N , N1 and N2 be point processes such that N1 is obtained from N by homogeneous independent thinning and N2 = N −N1. We give a new elementary proof that N1 and N2 are independent if and only if N is a Poisson point process. We present some applications of this result to test if a homogeneous point process is a Poisson point process.