Kunyit putih (Curcuma zedoaria) banyak digunakan oleh masyarakat luas karena dipercayai sebagai tanaman herbal yang bermanfaat dalam mengobati bermacam penyakit. Curcumin merupakan salah satu kandungan kunyit diyakini mempunyai manfaat antioxidan, anti inflamasi, mikroba, kanker, aterosklerosis dan diabetes. Secara umum, kepercayaan tehadap penggunaan pengobatan memiliki efek samping minimal ji...

Starch sweeteners are commonly used in many confectionery food products. Usually, considering the trend of producing low-energy and low-fat products, these products include fat mimetics. The aim this study was to investigate influence fructose on development functional properties MCG mimetic, such as rheological textural behavior. Fat mimetics made from Microcrystalline cellulose gel (MCG) cons...

1. Abstract: The objective of this work was to develop suitable film formulations of ketorolac tromethamine (KT) for transdermal use and to investigate the effect of film composition and permeation enhancers on the in-vitro release and skin permeation of the drug. Polyvinyl alcohol (PVA), sodium carboxymethylcellulose (NaCMC), and chitosan were used as film-forming polymers. The adhesive hydrop...

Jackfruit (Artocarpus heterophyllus) is a type of plant that grows in Indonesia which functions as food ingredient and traditional medicine. Generally, this genus contains prenylated flavonoid compounds. This study aimed to determine the anthelmintic effect jackfruit bark extract against Ascaris lumbricoides worms by utilizing total maceration with methanol solvent extraction method, yielded 6....

Clarithromycin (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor solubility is pH dependent. In this study, series of nanosuspensions containing CLM and stabilizer such as HPMC, NaCMC, polysorbate 80, poloxamer 188 and polyvinyl alcohol in various ratios were prepared using sonoprecipitation method. Briefly, CLM was ...

Carboxymethyl cellulose is widely used in many industrial aspects and also in laboratory due to its good biocompatibility. However, special researches on infrared especially aiming at the hydrogen bonds structure of carboxymethyl cellulose were relatively poor. We demonstrate here a full view of infrared spectroscopy in the temperature range of 40–220 C, mainly aiming at the hydrogen bonds in t...

The aim of this study was to improve the transdermal permeation of Diclofenac Soduim. Permeation studies were carried out in -vitro using Cellophane Membrane. Topical gel formulations of diclofenac sodium were prepared by using Carbopol 934, Carbopol 940, sodium carboxymethylcellulose (NaCMC), polymer as a gel-forming material that is biocompatible and biodegradable. The skin permeation enhance...

Gastroretentive tablets of propranolol hydrochloride were developed by direct compression method using citric acid and sodium bicarbonate as the effervescent base. Hydroxypropyl methylcellulose; HPMC K15M was used to prepare the floating tablets to retard the drug release for 12h in stomach. Na-carboxymethyl cellulose (NaCMC) or carbopol 934P was added to alter the drug release profile or the d...

Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action. The tablets were prepared by wet granulation method. The prepared tablets were coated with microporous semipermeable membrane and enteric polymer using conventional pan coating p...

BACKGROUND AND THE PURPOSE OF THE STUDY The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of mucoadhesive in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac and have good mucoadhesion with ocular mucus layers...