Harmicine is a β-carboline alkaloid isolated and identified as a major active compound present in many plant species and marine invertebrates. This alkaloid exhibits a wide spectrum of pharmacological activities, including antispasmodic, antipyretic, and anticancer properties. This report described the antinociceptive properties of harmicine by means of chemical experimental models in order to ...

BACKGROUND Recent events in the United States have led to increased security at national borders, resulting in an unexpected increase in drug seizures. In response, drug smugglers may begin using children as couriers, including using them as "body packers." OBJECTIVE To look at the occurrence of body packing, the concealing of contraband within the human body, which is well documented in adul...

Relative to sexually experienced male rats, sexually naive males typically display a pattern of copulatory behavior that is characterized by a larger proportion of rats that do not copulate: those that do copulate during their first exposure to a sexually receptive female have longer mount, intromission, and ejaculation latencies, and longer postejaculatory intervals. A male rat's first sexual ...

Nalbuphine hydrochloride is a relatively new agonist-antagonist drug structurally related to the potent narcotic, oxymorphone (Numorphan®), and the potent narcotic antagonist, naloxone (Narcan®). (Figure 1.) Nalbuphine has a potency equivalent to morphine sulphate and meperidine (10 mg morphine sulphate and 75 mg meperidine being equivalent to 20 mg nalbuphine), 1 with an abuse potential which ...

We learned previously that red-winged blackbirds (Agelaius phoeniceus) use affective processes to shift flavor preference, and cognitive associations (colors) to avoid food, subsequent to avoidance conditioning. We conducted three experiments with captive red-winged blackbirds to reconcile varied consequences of treated food with conditioned sensory cues. In Experiment 1, we compared food avoid...

In many animal species, as well as in humans, high doses of fentanyl (F) produce marked neurotoxic effects, such as muscular rigidity and respiratory depression. The antinociception (hot-plate test), impairment of motor coordination (rotarod test) and acute toxicity of intraperitoneal newly synthesized analogs, (±)cis-3-carbomethoxyfentanyl (C) and (±)trans-3-carbomethoxyfentanyl (T) were evalu...

Tail flick test in rats and acetic acid induced writhing in mice were employed to study the antinociceptive activity of ethanolic leaf extract of Vitex-negundo (VN) (100, 250 and 500 mg/kg, p.o). The effect was compared with meperidine (40 mg/kg, sc) in tail flick method and aspirin (50 mg/kg, p.o) in writhing test as a standard control respectively. An interaction with naloxone hydrochloride w...