Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication technologies, and microfluidics. Recent advances in drug administration techn...

Nanotechnology is the new emerging technology in the drug discovery and it has the property of self targeting in the sense that without the attachment of a specific ligand, the nanoparticles can be used for targeting, due to their distinctively small size, at the infected pathological areas. Drug delivery system fetched a novel drug delivery system, a novel approach to overcome the drawbacks of...

Cisplatin (cis-(diammine)dichloridoplatinum(II)) is the first platinum-based compound approved by United States Food and Drug Administration (FDA) (U.S.). This a first-line chemotherapeutic treatment used alone or combined with other anticancer drugs to treat broad spectrum of malignancies, cisplatin-based nano-formulations currently in clinical studies. has several drawbacks, including low aqu...

Objective. The objective of the present study is to synthesize and optimize bovine serum albumin nanoparticles coated with ofloxacin drug nano conjugate and evaluation of control release and anti bacterial activity against clinical isolate of Pseudomonas aeruginosa,Methods.Simple coacervation technique was implemented for preparation of BSA nanoparticles and optimization was carried out with va...

background sinusitis is one of the most prevalent infectious diseases among those who visit doctor, which requires antibiotic intervention. the most common types of bacteria causing this disease are streptococcus pneumonia, streptococcus pyogenes, staphylococcus aureus and pseudomonas aeroginosa. nonetheless due to dangerous side effects of chemical drugs on body and increased drug resistance o...

A novel photo-responsive nano-container was successfully constructed based on well-defined vesicles formed by an amphiphilic overcrowded alkene switch. The nano-container could adjust its inner volume in reversible photo/heat controlled mode, which could show potential in remote drug delivery systems.

Biodegradable nanoparticles are being considered more often as drug carriers to address pharmacokinetic/pharmacodynamic issues, yet nano-product safety has not been systematically proven. In this study, haematological, biochemical and histological parameters were examined on 28 day daily dosing of rats with nano- or micro-particle encapsulated cyclosporine (CsA) to confirm if any changes observ...

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical ...

Although, the drug delivery system (DDS) concept is not new, great progress has recently been made in the treatment of a variety of diseases. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of DDS. To convey a sufficient dose of drug to the lesion, suitable carriers of drugs are needed. Nano and microparticle carriers have important potential application...