Dermatan sulfates and heparin, similar to the mammalian glycosaminoglycans, but with differences in the degree and position of sulfation were previously isolated from the body of the ascidian Styela plicata and Ascidia nigra. These differences produce profound effects on their anticoagulant properties. S. plicata dermatan sulfate composed by 2-O-sulfated alpha-L-iduronic acid and 4-O-sulfated N...

We previously purified a putative sulfated-galactosylceramide (sulfatide)-binding protein with a molecular weight of 47 kDa from the cell surface of Lactobacillus reuteri JCM1081. The aim of this study was to identify the 47-kDa protein, examine its binding to sulfated glycolipids and mucins, and evaluate its role in bacterial adhesion to mucosal surfaces. By cloning and sequencing analysis, th...

Gekko swinhonis Guenther has been used as an anti-cancer drug in traditional Chinese medicine for hundreds of years. Previous studies showed that the Gekko sulfated polysaccharide-protein complex suppressed the proliferation and migration of hepatoma cells. Gekko sulfated glycopeptide α was obtained from Gekko sulfated polysaccharide-protein complex using papain hydrolysis. Gekko sulfated glyco...

Repair of osteochondral defects created in rabbit femoral trochlea were studied using a water-soluble sulfated p-GlcNAc formulation, (Marine Polymer Technologies, Danvers, MA, USA). After 12 weeks of healing empty defects were compared to defects filled with sulfated p-GlcNAc sponge alone and sulfated p-GlcNAc sponge seeded with autologous chondrocytes. The chondrocyte seeded sponge provided th...

Sulfated tetrafucosides with different sulfation patterns, and a non-sulfated tetrafucoside , were designed and systematically synthesized from the common key intermediate . In addition, their anti-proliferative activities and apoptosis-inducing activities against human breast cancer MCF-7 cells were evaluated. Our results demonstrated that the sulfated tetrafucosides reduced the number of MCF-...

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly blocks the terminal differentiation of normal cul tured Chondroblasts. In TPA, the chondroblasts lose their char acteristic polygonal morphology and initiate the synthesis of an atypical type IV sulfated proteoglycan. This atypical proteoglycan has lower molecular size, shorter polysaccharide chains, and different 4S-disaccha...

Dengue represents a serious social and economic public health problem; then trying to contribute to improve its control, the objective of this research was to develop phytoterapics for dengue treatment using natural resources from Caatinga biome. Galactomannans isolated from Adenanthera pavonina L., Caesalpinia ferrea Mart., and Dimorphandra gardneriana Tull were chemically sulfated in order to...

Intake of sulfated polysaccharides, such as fucoidan or lambda-carrageenan extracted from seaweeds, has been shown to enhance immune responses, resulting in inhibition of tumor growth. However, little is known about the mechanisms by which these sulfated compounds mediate the enhancement. In the present study, we examined the effect of sulfated polysaccharides from seaweeds on esterase activity...

Chemical communication is widespread in amphibians, but if compared to later diverging tetrapods the available functional data is limited. The existing information on the vomeronasal system of anurans is particularly sparse. Amphibians represent a transitional stage in the evolution of the olfactory system. Most species have anatomically separated main and vomeronasal systems, but recent studie...