Acyclovir (ACV) is a promising candidate for drug repurposing because of its potential to provide an effective treatment viral infections and non-viral diseases, such as cancer, which limited options exist. However, poor physicochemical properties limit application. This study aimed formulate evaluate ACV-loaded red clay nanodrug delivery system exhibiting cytotoxicity. The focused on the prepa...

this survey was carried out on children less than five years of age from rural areas of three provinces in iran (west azarbaijan, bushehre, and central province), with different health care delivery systems and various types of immunization scheme, to determine the immune status of measles and the vaccine coverage. our results indicate that the rates of measles immunity and vaccine coverage for...

A nanodrug delivery system of paclitaxel-mesoporous silica nanoparticles with a core-shell structure (PAC-csMSN) was used to increase the dissolution of paclitaxel (PAC) and improve its treatment of lung cancer. PAC was loaded into the core-shell mesoporous silica nanoparticles (csMSN) by the adsorption equilibrium method and was in an amorphous state in terms of its mesoporous structure. In vi...

Chemotherapy has been widely used in breast cancer patients to reduce tumor size. However, most anticancer agents cannot differentiate between cancerous and normal cells, resulting in severe systemic toxicity. In addition, acquired drug resistance during the chemotherapy treatment further decreases treatment efficacy. With the proper treatment strategy, nanodrug carriers, such as liposomes/immu...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

since hospitals are an important and integral part of the overall health delivery system, this study was carried out to measure the effectiveness of this institution within the system. the records of 633 hospitalized patients in the pediatrics ward of ghaem hospital in mashhad during 1357 (21 march 1978-20 march 1979) has been consulted. more than half of the patients were hospitalized with the...