Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective: Generation of non-toxic, cell-compatible cationic nanoliposomes as nanot...

Omega-3 fatty acids (FAs) have been shown to prevent cardiovascular disease. The most commonly used omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly vulnerable to oxidation and therefore, have short shelf life. Recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 FAs. Several methods could be implemented to prepar...

background it has been shown that topical nanoliposomal formulations improve burn healing process. on the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. present investigation studies permeation of clindamycin phosphate (cp) through burn eschar from li...

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Metformin hydrochloride, a drug group of biguanides, with significant efficacy in the treatment of diabetes type II, is decomposed before reaching to the stomach and is wasted in great losses. In this study, the nanoliposomes of metformin hydrochloride were prepared with Bingham method. At first, the single factor test is done. Design variables are: lecithin to cholesterol ratio, organic solven...

Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of silymarin in fre...

Abstract Background Apigenin (4?, 5, 7-trihydroxyflavone), a flavonoid, is present usually in fruits and vegetables possessing numerous biological properties like antioxidant, anti-viral, antibacterial, anti-inflammatory, chemoprevention activity. So study was aimed to prepare characterize nanoliposomes of apigenin estimate its encapsulation efficiency by stability-assisted reverse-phase (RP)-H...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...

the use of bacteriocins, mainly nisin, is one of the most significant preservation technologies in the food industry. nisin encapsulation can improve stability and homogenous distribution in food matrices. in this study, liposomes of four various lipids (lipoid s 100, lipoid s pc-3, lipoid s pc, and lipoid pc (dppc)) were prepared by dehydration-rehydration method, and compared for entrapment e...

Nanoliposomes are drug release systems that increase bioavailability and used for encapsulation of therapeutic active ingredients. Terebinth, which is a medicinal plant grows in many parts Türkiye, has antibacterial, antioxidant, anti-inflammatory activity. The antibacterial activity nanoliposomes incorporated with ethanol extract terebinth leaves (TLE) was investigated to determine the effects...