The field of ocular drug delivery is one the most interesting and challenging fields for Formulation Scientists or Pharmacists. In ophthalmic in situ gel many polymers are used which form by various mechanisms like pH-sensitive thermo sensitive gel. We can make instead an solution to overcome problem low bioavailability. Some common diseases cured blepharitis, conjunctivitis, keratitis, trachom...

In-situ forming polymeric formulations drug delivery systems is in solution form before administration in the body, but once administered, undergoes gelatin in-situ to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-violet irradiation, from which drug gets released in sustained and controlled manner. The object of this ...

despite the great potential of graphene as a nanofiller, achieving homogeneous dispersion remains the key challenge for effectively reinforcing polyolefin (such as polyethylene (pe) and polypropylene (pp)) nanocomposites. therefore, in this research, we report a facile combined in situ polymerization and masterbatch method for fabricating pp/reduced graphene oxide (rgo) nanocomposites. in the p...

Smart polymeric systems represent promising means of delivering the drugs; these polymers undergo sol-gel transition, once administered. In-situ gel structure occurs due to one or combination of different stimuli like pH change, temperature modulation and ionic exchange. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiatio...

Alterations in the gut microbiota have been recently linked to oral iron. We conducted two feeding studies including an initial diet-induced iron-depletion period followed by supplementation with nanoparticulate tartrate-modified ferrihydrite (Nano Fe(III): considered bioavailable to host but not bacteria) or soluble ferrous sulfate (FeSO4: considered bioavailable to both host and bacteria). We...

High-spatial-resolution secondary ion microprobe spectrometry, synchrotron radiation-based Fourier-transform infrared spectroscopy, and polyacrylamide gel analysis demonstrated the intimate association of proteins with spheroidal aggregates of biogenic zinc sulfide nanocrystals, an example of extracellular biomineralization. Experiments involving synthetic zinc sulfide nanoparticles and represe...

The removal of potentially harmful radioactive waste from the anthroposphere will require disposal in geological repositories, designs which often favour inclusion a clay backfill or engineered barrier around waste. Bentonite is proposed as this and understanding its long-term performance behaviour vital establishing safety case for usage. There are many different compositions bentonite that ex...

A hydrogel-based functional hybrid with highly uniformly dispersed nanoparticulate CdS semiconductors is proposed. The hybrid is synthesized using an in situ polymerization following an in situ chemical reduction, where the resulting particle size and the distribution of CdS nanocrystals (NCs) can be narrowly manipulated. The hybrids, containing a relatively small amount of the CdS NCs, exhibit...

purpose : to investigate the sensations experienced by chinese patients during refractive surgery including the laser in situ keratomileusis (lasik), epi-lasik, and sub-bowman keratomileusis (sbk) techniques. a prospective, randomized, and self-matched clinical study was conducted. methods : the participants included 44 men and 58 women aged 16 to 47 years old (mean 24.3±0.6 years) who underwen...