Current theranostics for neurodegenerative diseases (NDD) management are majorly symptomatic due to a lack of identification early-stage biomarkers and the inefficiency drugs penetrate through blood-brain barrier. Recently, Neuro-nanotechnology interface has emerged as potential strategy diagnosis, monitoring, treatment NDDs owing smaller particle size, high specific surface area, tunable physi...

FK-506 binding protein (FKBP12) is a protein of the family of immunophilins, involved in many neurodegenerative diseases such as Alzheimer’s syndrome where FKBP12 is known to be over-expressed in early stages of the disease. We designed and built Langmuir-Blodgett nanostructures incorporating ligands with high affinity for FKBP12: Tacrolimus (FK506) and Rifaximin as candidate nanosensors to det...

Multivalent effects dictate the binding affinity of multiple ligands on one molecular entity to receptors. Integrins are receptors that mediate cell attachment through multivalent binding to peptide sequences within the extracellular matrix, and overexpression promotes the metastasis of some cancers. Multivalent display of integrin antagonists enhances their efficacy, but current scaffolds have...

Ischemic heart conditions are some of the most prevalent disorders in the United States. These diseases also cause a significant number of mortalities each year. Despite considerable advances in treatment of the ischemic and infarct heart, many patients still develop complications and often progress to heart failure. These outcomes are typically related to factors such as the inability to deliv...

Controlled nucleation of nanoscale building blocks by geometrically defined seeds implanted in DNA nanoscaffolds represents a unique strategy to study and understand the dynamic processes of molecular self-assembly. Here we utilize a two-dimensional DNA origami frame with a hollow interior and selectively positioned DNA hybridization seeds to control the self-assembly of DNA tile building block...

Nano science and nanotechnology have revolutionized all aspects in the endodontic field. The aim of the present study was to describe the application of nanotechnology in endodontics by reviewing the literature.The application of nanomaterials, with a smaller size, for surface modification has reduced the incidence of failure in the rotary nickel-titanium files. Nanoparticles with the ability o...

There is an increasing demand for formulations of silk fibroin (SF) scaffolds in biomedical applications. SF was crosslinked via glutaraldehyde with osteoinductive recombinant human bone morphogenic protein-2 (rhBMP2) of different ratios viz. (i) 3% SF with no rhBMP2 (SF), (ii) 3% SF with equal amount of rhBMP2 (SF+BMP2), and (iii) 12% SF with 3% of rhBMP2 (4SF+BMP2), and these solutions were u...

Nanomaterials are known as chemically or biologically engineered materials having nanodimension of 1-100nm. These have been shown to exhibit various novel properties e.g. enhanced reactivity, greater sensing capability and improved mechanical strength. Various improved procedures are still under innovative considerations to enhance the potency, safety, and efficiency of chosen plasmid DNA vecto...