Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin t...

Structural analysis and nanosizing of gene domains requires not only high-resolution microscopy but also improved techniques of fluorescence labelling strongly focussed on the gene domains. To investigate the architecture of abl and bcr in blood cell nuclei forming the Philadelphia chromosome in CML, we applied COMBO-FISH using specifically colocalising combinations of triple strand forming oli...

Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson's disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived...

CONTEXT Diacerein (DCN) has low aqueous solubility (3.197 mg/L) and, consequently, low oral bioavailability (35%-56%). To increase both the solubility and dissolution rate of DCN while maintaining its crystalline nature, high pressure homogenization was used but with only a few homogenization cycles preceded by a simple bottom-up technique. METHODS The nanosuspensions of DCN were prepared usi...

The non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmaceuticals worldwide. Interestingly, many of them have significant anticancer properties too. However, the poor water solubility of certain NSAIDs limits their application for cancer treatment. Nanosizing of such drugs can help to improve the solubility and this may result in enhanced anticancer activities too. Mor...

The non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmaceuticals worldwide. Interestingly, many of them have significant anticancer properties too. However, the poor water solubility of certain NSAIDs limits their application for cancer treatment. Nanosizing of such drugs can help to improve the solubility and this may result in enhanced anticancer activities too. Mor...

In recent years, significant effort has been devoted to the development of drug formulation with the purpose of targeting and controlled release. The micro/nanosizing of drugs has been identified as a potentially effective and broadly applicable approach. In the pharmaceutical industry several conventional techniques have been utilized for particle size reduction. The disadvantages of these tec...

Although nanosizing Li4Ti5O12 (LTO) materials is an effective way to improve their rate performances, their low tap density and first cycle coulombic efficiency limit their practical applications. To tackle these problems while preserving the advanced rate performances, monodispersed mesoporous LTO submicrospheres are developed here. These submicrospheres are synthesized via a solvothermal meth...

Pharmacometric analysis of clinical microdialysis data – Adequacy of standard linezolid dosing in different patient groups Identification of novel viral protease inhibitors via dynamic fragment ligation Using structure-and Ligand-based pharmacophores as filters to discriminate Human Aryl Sulfotransferase 1A1 (SUL1A1) binders into substrates and inhibitors Discovery of novel α-amylase inhibitors...