In Escherichia coli K-12 the expression of many genes is controlled by the oxygen-responsive transcription factor FNR and the nitrate- and nitrite-responsive two-component systems NarXL and NarPQ. Here, the ydhY gene is shown to be the first gene of a six-gene operon (ydhYVWXUT) that encodes proteins predicted to be components of an oxidoreductase. Mapping the ydhY-T transcript start and site-d...

Abstract Background and Aims There is a growing awareness among Canadian health care providers of the need to incorporate virtual consultations safely effectively post pandemic. With onset Covid-19 pandemic in March 2020, outpatient consultation Northern Alberta Renal Program (NARP) was rapidly transitioned delivery (telephone or videoconferencing) place face-to-face visits. To scale up sustain...

C ountries around the world are striving to end theHIV/ AIDSpandemic by focusing on the “90-90-90 targets” of the Joint United Nations ProgramonHIV/AIDS. By 2020, 90 percent of people living with HIVwill know their HIV status, 90 percent of those diagnosed with HIV will be on treatment, and 90 percent of those treated will have effective viral suppression. Namibia had a 14 percent HIV prevalenc...

Interactions between GluR2 and N-ethylmaleimide-sensitive factor (NSF) mediate AMPA receptors trafficking. This might be linked with molecular mechanisms related with memory formation. Previous research has shown basolateral amygdala (BLA) dependent activity changes in the perirhinal cortex (PRh) during the formation of taste memory. In the present experiments we investigate both the behavioral...

When mitochondrial diseases result from mutations found in the mitochondrial DNA, engineered mitochondrial-targeted nucleases such as mitochondrial-targeted zinc finger nucleases are shown to specifically eliminate the mutated molecules, leaving the wild-type mitochondrial DNA intact to replicate and restore normal copy number. In this issue, Gammage and colleagues successfully apply this impro...