Kank1, which was first described as a potential tumor suppressor for renal cell carcinoma (RCC), mapped to 9p24.3 and encoded an ankyrin-repeat domain-containing protein. Its frequent deletion was found to be associated with several human malignant tumors, cerebral palsy, and neuronal and developmental diseases. However, its functional role in nasopharyngeal cancer (NPC) was still unknown. In t...

Detection of nodal metastasis in the neck or adjacent structures is common in nasopharyngeal carcinoma (NPC) when there is frank primary disease. Intracranial extension without obvious nasopharyngeal disease is not common. Here, we discuss a patient with NPC that presented with extensive intracranial disease with subtle findings in the nasopharynx.

Nasopharyngeal carcinoma (NPC) is common among southern Chinese including the ethnic Cantonese population living in Hong Kong. Epstein-Barr virus (EBV) infection is detected in all undifferentiated type of NPC in this endemic region. Establishment of stable and latent EBV infection in premalignant nasopharyngeal epithelial cells is an early event in NPC development and may contribute to its pat...

BACKGROUND Recruit training sites are places with a high incidence of respiratory infectious diseases. Effective surveillance for acute respiratory infectious diseases in a recruit training site is an important way to prevent disease outbreaks. METHODS Eight hundred recruits (722 males and 78 females) enlisted in autumn 2015 received a background survey within 24 h of settlement at the recrui...

In this study, we aimed to use the combined detection of multiple antibodies against Epstein-Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopha...

Epistaxis is simply known as nose bleeding, presented as hemorrhage from the nasal cavity which is noticed when blood flows out through nostrils. Nasal bleeding may occur due to nasal cavity and sinus disease, nasopharyngeal lesions, cavernous sinus lesions, rupture of artery and false aneurysm, some systemic diseases can also cause nasal bleeding. We describe an uncommon cause of epistaxis in ...

RATIONALE Nasopharyngeal amyloidosis is a benign, slowly progressive disease that is characterized by extracellular eosinophilic deposition. PATIENT CONCERNS We report a rare case of localized nasopharyngeal amyloidosis. DIAGNOSES The initial chief complaint of this patient was frequent epistaxis and right aural fullness. The initial diagnosis was nasopharyngeal tumor. INTERVENTIONS There...

ELEVATIONS OF LEVELS OF SERUM antibodies to Epstein-Barr virus (EBV) occurring several years before diagnosis have been characteristically found in diseases probably caused by EBV, such as Burkitt lymphoma and nasopharyngeal carcinoma, and in Hodgkin disease. Anti-EBV antibodiesareelevatedinindividualswith multiple sclerosis (MS), and a premorbid increase has been reported in 2 studies, but bot...

BACKGROUND & OBJECTIVE Nasopharyngeal necrosis is an unusual sequelae after radiotherapy for nasopharyngeal carcinoma (NPC). It is mostly managed by conservative treatment, but the efficacy is unsatisfied. This study was to investigate the efficacy of endoscopy-guided debridement on irradiation-related nasopharyngeal necrosis in NPC patients after radiotherapy. METHODS Between Jul. 2006 and M...

This first 62 pages are taken up with the anatomy of the ear. It is a curious omission that no connected description of the tympanic cavity is attempted, though every other part of the ear is so described. A short chapter on the physiology of the ear is followed by others on its bacteriology and on the causation of its diseases. The diseases themselves are the subject of the rest of the volume....