A simple evolutionary model is presented which explains why organisms produce so many natural products, why so many have low biological activity, why enzymes involved in natural product synthesis have the properties they do and why natural product metabolism is shaped as it is.

After an initial period of validating asymmetric organocatalysis by using a wide range of important model reactions that constitute the essential tools of organic synthesis, the time has now been reached when organocatalysis can be used to address specific issues and solve pending problems of stereochemical relevance. This Review deals with selected studies reported in 2006 and the first half o...

Fusarins G1/G2 (1/2) and G3/G4 (3/4), two sets of interesting examples of diastereoisomers with substantially identical NMR data, were discovered from natural products. The reason was discussed and the generally applicable determinant conditions were proposed. The minimum interval for stereoclusters to be entirely segregated was also discussed.

A spiro[5.5]ketal library embodying the core structure of numerous biologically active natural products was synthesized employing a double intramolecular hetero Michael reaction as a key transformation.

Natural antimicrobials are secondary metabolites that can be found in plants, animals, and microorganisms.Plants, especially herbs and spices, are been given more attention in natural antimicrobial research, however; this chapter focuses on the newly discoveries in fruits and vegetables. Microorganisms that are been used in food fermentation also produce different antimicrobial metabolites incl...

The efficiency of antibiotics in combating microbial infections was very promising shortly after their introduction. It was even thought that the microbial war was as good as over as was declared by the Surgeon General of the United States. However, resistance to these agents developed rapidly afterward and the problem of antibiotic resistance has remained a menace threatening the benefits of a...

This review covers the marine natural products literature for the year 2000 and is organized phylogenetically, with sections on marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates. echinoderms and miscellaneous marine organisms. There is an emphasis on new structures, stressing their biological activities, source o...

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