Nei and Tajima (1985) recently have criticized my algorithms (Templeton 1983a, 19833) that make phylogenetic inference from restriction-site maps. The purpose of this letter is to address their criticisms and to examine the reasons for our difference of opinion concerning the range of validity of my algorithms. These points will also be illustrated by a worked example using Hawaiian Drosophila....

Named Entity Identification/Recognition is a key component for most Information Extraction tasks. All the existing approaches for NEI use extensive language specific resources. This paper deals with the problem of Multi lingual Named Entity Identification (NEI), and explains the need to address this problem in a language independent fashion. In this work we focus on Less Resourced languages lik...

The National Eye Institute (NEI) hosted a workshop on November 19, 2014, as part of the Audacious Goals Initiative (AGI), an NEI-led effort to rapidly expand therapies for eye diseases through coordinated research funding. The central audacious goal aims to demonstrate by 2025 the restoration of usable vision in humans through the regeneration of neurons and neural connections in the eye and vi...

BACKGROUND Commonly used vision-targeted health-related quality of life questionnaires almost exclusively focus items on vision under daytime conditions. Older adults even when in good eye health frequently report experiencing vision problems at night and under low environmental light levels, and psychophysical studies also document these visibility problems. Here we compare the progression of ...

Agglomerative algorithms iteratively pick a pair of taxa, create a new node that represents the cluster of these taxa, and compute a new distance matrix with reduced size where both taxa are replaced by this node. The cycle is repeated until the number of taxa becomes three (or two for rooted trees). This general scheme was first applied to additive unrooted trees by Sattath and Tversky (ADDTRE...

One of the goals of the recent workshop, “An Eye on Glaucoma: New Opportunities for Treatment,” was to highlight areas of glaucoma research that, with appropriate funding, are ripe for major advancement for prevention, diagnosis, and treatment. Another goal was the exploration of collaborative partnership and the process for facilitating translation of these areas, not just for glaucoma but for...

Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identified from a UK hospital-based glaucoma service database. Trends were assessed in ...

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC to T transitions. Mammalian cells have high levels of activity of 5hmU-DNA glycosylase, which excises 5hmU from DNA. However, ...

The 5-formyluracil (5-foU), a major mutagenic oxidative damage of thymine, is removed from DNA by Nth, Nei and MutM in Escherichia coli. However, DNA polymerases can also replicate past the 5-foU by incorporating C and G opposite the lesion, although the mechanism of correction of the incorporated bases is still unknown. In this study, using a borohydride-trapping assay, we identified a protein...