Understanding and solving biomedical problems requires insight into the complex interactions between the components of biomedical systems by domain and non-domain experts. This is challenging because of the enormous amount of data and knowledge in this domain. Therefore, non-traditional educational tools have been developed such as a biological storytelling system, animations of biomedical proc...

BACKGROUND AND OBJECTIVES Bacterial meningitis is one of the most serious infections and should be treated as emergency. As it has significant morbidity and mortality throughout the world, every country should have precise information regarding the etiological agents of disease and populations at risk to design public health prevention strategy. In the present study in addition of evaluation of...

Immunity to meningococcus: The role of humoral antibodies. J Exp Med. 1969;129:1307-26. 8. Santos GF, Deck RR, Donnelly J, Blackwelder W, Granoff DM. Importance of complement source in measuring meningococcal bactericidal titers. Clin Diag Lab Immunol.2001;8:616-23. 9. Aggarwal M, Manchanda V, Talukdar B. Meningitis due to Neisseria meningitides serogroup B in India. Indian Pediatr. 2013;50:601...

In this research, we successfully expressed recombinant CMP-sialic Acid Synthetase (CSS) from Neisseria meningitides and 2,6-Sialyltransferase (SAT) from Photobacterium damsela in E. coli BL21(DE3) fermented at a scale of up to 8 litres using individual plasmids pIRL-1 and pIRL-4b, respectively. After cell lysis with BugBuster, enzyme levels of 2U and 22U per litre were produced for CSS and SAT...

Neisseria meningitidis is a cause of several life-threatening diseases and can be a normal commensal in the upper respiratory tract of healthy carriers. The carrier rate is not well established especially because there is no standard method for the isolation of N. meningitidis. Therefore, the aim of this study was to compare identification methods for the carrier state. Two swabs were collected...

The current therapy for glioblastoma multiforme involves total surgical resection followed by combination of radiation therapy and temozolomide. Unfortunately, the efficacy for such current therapy is limited, and newer approaches are sorely needed to treat this deadly disease. We have recently described the isolation of bacterial proteins and peptides with anticancer activity. In phase I human...

objective: bacterial meningitis is a dangerous and sometimes fatal infection that affects the central nervous system. because some antibiotics can prevent some types of these bacteria and supress them from spreading and infecting, therefore it is important to know what type of virus or bacterium is causing meningitis. haemophilus influenzae and neisseria meningitides are the two main pathogens...

Various gram-negative pathogens possess secreted or outer membrane proteins (OMPs) which interact with host cytokines. Of periodontal pathogens only Aggregatibacter actinomycetemcomitans (Aa) has been shown to sequester and uptake cytokines. We have identified two (OMPs) of Aa, bacterial interleukin receptor I (BilRI) and OM secretin channel (OMS), which interact with several cytokines, the int...