background & aim:  high-risk pregnancies increase the risk of intensive care unit (icu) and neonatal intensive care unit (nicu) admission in mothers and their newborns. in this study, we aimed to identify the association between the recurrence of high-risk pregnancy and mothers’ previous experience of having an infant admitted to nicu. methods:we performed a cohort, retrospective study to compa...

We report an infant with intrauterine growth retardation and transient neonatal diabetes who has paternal uniparental disomy for chromosome 6. The infant was not dysmorphic and had no congenital anomalies. To our knowledge, this is the third case of paternal uniparental disomy occurring in an infant with transient neonatal diabetes, thus confirming the association.

Diabetes mellitus has many forms. Neonatal diabetes mellitus is one of the rarest, with a reported incidence of 1 in 450,000 live births.1 2 The first case was described by Kitselle (1 852) in his own newborn son, who subsequently died.3 In Northern Ireland, one case might be expected approximately every 16 years; the lastdocumented here was born in 1983.4 Several literature reviews have highli...

Neonatal diabetes mellitus, which is defined as hyperglycemia presenting within the first six weeks of life, is a rare disorder. It may result in transient or permanent disease. Pancreatic agenesis is a rare cause of neonatal diabetes.We report a neonate who was small for gestational age and presented with diabetes mellitus and signs of malabsorption because of pancreatic agenesis.

There have been few case reports of isolated elevation of alkaline phosphatase beyond the normal physiologic amount with subsequent return to baseline after delivery. Here we present a similar case of extreme elevation of alkaline phosphatase in a pregnancy complicated by gestational diabetes and subsequently by neonatal alloimmune thrombocytopenia (NAIT).

AIMS Recessive PDX1 (IPF1) mutations are a rare cause of pancreatic agenesis, with three cases reported worldwide. A recent report described two cousins with a homozygous hypomorphic PDX1 mutation causing permanent neonatal diabetes with subclinical exocrine insufficiency. The aim of our study was to investigate the possibility of hypomorphic PDX1 mutations in a large cohort of patients with pe...

BACKGROUND Neonatal diabetes is a rare cause of hyperglycemia, affecting 1: 500,000 births, with persistent hyperglycemia occurring in the first months of life lasting more than 2 weeks and requiring insulin. This condition in infants less than 6 months of age is considered as permanent neonatal diabetes mellitus. CASE REPORT A rare case of permanent neonatal diabetes mellitus presented with ...

insulin is currently the drug of choice in treating patients with gestational diabetes mellitus but insulin is expensive, inconvenient to store and use and probably associated with more risks of asymptomatic hypoglycemia in comparison with some oral agents. this randomized clinical trial was conducted to evaluate the efficacy and safety of glyburide in patients with gestational diabetes mellitu...

changes in the diagnosis and treatment of diabetes presenting in the first 6 months of life. It is now known that this form of diabetes, which develops in the neonatal period, is often caused by a change in a single gene (monogenic) and is not type 1 diabetes (Slingerland and Hattersley, 2005; Edghill et al, 2006). These major changes have resulted from the identification of neonatal diabetes a...