PURPOSE To determine the efficacy of photodynamic therapy (PDT) with verteporfin (Visudyne; Novartis AG, Basel, Switzerland) for treatment of corneal neovascularization in a rabbit eye model. METHODS Corneal neovascularization was induced in Dutch belted rabbits by placing an intrastromal silk suture near the limbus. Verteporfin was administered by intravenous injection at a dose of 1.5 mg/kg...

TOPIC To assess the evidence for the effectiveness of interventions to improve visual acuity (VA) and prevent or treat neovascularization secondary to central retinal vein occlusion (CRVO). CLINICAL RELEVANCE Central retinal vein occlusion is a common cause of visual morbidity and blindness. Many different interventions have been advocated, but the evidence justifying their use remains unclea...

Human hepatocyte GF (hHGF) has strong neoangiogenesis activity. The present study was designed to investigate the possible involvement of hHGF in neovascularization in proliferative diabetic retinopathy (PDR) by measuring vitreous hHGF concentrations. The mean vitreous hHGF concentration was higher in subjects with PDR (5.70 +/- 0.68 ng/mL, n = 33) than in nondiabetic control subjects (1.50 +/-...

We report a 64-year-old diabetic woman who developed neovascularization of the posterior capsule 2 years after cataract surgery and intraocular lens implantation. The patient was treated with single injection of 1.25 mg of intravitreal bevacizumab (Avastin) via pars plana. After one week, complete regression of the posterior capsule neovascularization was achieved allowing us to perform Nd: YAG...

PURPOSE Thrombospondin (TSP)-1 and -2 are important antiangiogenic factors thought to be involved in maintaining corneal avascularity (angiogenic privilege). This study was undertaken to investigate whether deficiencies of these factors altered developmental and inflammation-induced angiogenesis in the cornea and developmental angiogenesis of the iris of mice. METHODS Expression of TSP-1 and ...

Two well controlled non-insulin dependent diabetics with background retinopathy underwent endocapsular lens extraction with in-the-bag posterior chamber implantation. In the postoperative period rubeosis iridis set in abruptly. The fellow eyes showed no progression of retinopathy and the diabetic status showed no deterioration. The cause of neovascularisation and the role of intra- versus extra...

A female presented to the eye outpatient department with the chief complaint of blurred vision, pain, and redness in the left eye for 2 days. Visual acuity in the right eye was 6/6 and hand movement close to face in the left eye. Slit lamp examination left eye revealed a superior hypopyon, +3 cells in the anterior chamber, and iris neovascularization [Figures 1 and 2]. Intraocular pressure by n...

BACKGROUND To evaluate the success rate and adverse effects of Gold Micro Shunt Plus (GMS+) implantation into the supraciliary space. METHODS This retrospective study included 31 eyes of 31 patients diagnosed with severe glaucoma and uncontrolled intraocular pressure (IOP) with implantation of a GMS+ by means of a full-thickness scleral flap. The main outcome measures were surgical failure or...

purpose : to determine the distribution of iris colors in the population of tehran and to assess possible associations between iris color and ocular disorder methods : through a stratified random cluster sampling approach, 160 clusters were selected in different municipality districts of tehran, and the approached households were invited to a clinic. after the initial interview, all participant...