The toxicities of ethylene glycol (EG) and ethylene glycol monoethyl ether (EGEE) were studied in Fischer 344/N rats and B6C3F1 mice. In a 13-week study, EG was administered in feed to groups of 10 rats and 10 mice of both sexes at dose levels of 0 (control), 0.32, 0.63, 1.25, 2.5 and 5.0%. Kidney/body weight ratios were elevated in the 2.5 and 5.0% dose groups of male and female rats relative ...

In 1923, not many years after Epstein's (1) original characterization of lipoid nephrosis, Salvesen and Linder (2) first observed a lowering of the serum calcium concentration which paralleled the decrease in serum protein level in patients with this disease.' In addition, two other features indicating a disturbance of calcium metabolism in nephrosis have been described. Boyd, Courtney, and Mac...